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    Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway

    Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway by Xiaoyan Bi, Xinhui Huang, Chunmei Zhang, Xin Zhao, Junyu Ma, Mengyao Li, Xuexun Li, Bangzhao Zeng, Rong Li, Xian Zhang, Fuli Ya

    Published 2025-08-01

    BackgroundPlatelet abnormalities are well-recognized complications of type 2 diabetes mellitus (T2DM). High glucose (HG) increases platelet mitochondrial dysfunction, apoptosis and hyperreactivity in T2DM, which underlie the occurrence of thrombotic events. Sulforaphane (SFN) is a dietary isothiocya...

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