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    Synthesis of Novel Tetra-Substituted Pyrazole Derivatives Using Microwave Irradiation and Their Anti-Leukemic Activity Against Jurkat Cells

    Synthesis of Novel Tetra-Substituted Pyrazole Derivatives Using Microwave Irradiation and Their Anti-Leukemic Activity Against Jurkat Cells by Felipe P. Machado, Maria Clara Campos, Juliana Echevarria-Lima, Diego P. Sangi, Carlos Serpa, Otávio Augusto Chaves, Aurea Echevarria

    Published 2025-07-01

    Three previously synthesized ketene dithioacetals were used as intermediates to obtain four nucleophiles to synthesize ten tetra-substituted pyrazoles (<b>11</b>–<b>20</b>). This was achieved through microwave irradiation in ethanol as the solvent, yielding superb results ran...

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