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    Delivering LINE1 antisense oligonucleotides via endothelial targeting extracellular vesicles to ameliorate myocardial infarction-induced cardiac senescence

    Delivering LINE1 antisense oligonucleotides via endothelial targeting extracellular vesicles to ameliorate myocardial infarction-induced cardiac senescence af Enze Fu, Kai Pan, Benjamin Hinnant, Shang Chen, Zhibo Han, Zhikun Guo, Zhong-chao Han, Qiong Li, Zongjin Li

    Udgivet 2025-11-01

    Transposable elements (TEs) constitute a significant portion of the nuclear genome, but their influence on and ability to manage their activity during tissue regeneration remain largely unknown. Here, we revealed that LINE1, the most abundant TE, responds to cardiomyocyte injury and is overexpressed...

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