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    Multi-omics whole-genome characterization of the copy number landscape of metastatic pancreatic ductal adenocarcinoma

    Multi-omics whole-genome characterization of the copy number landscape of metastatic pancreatic ductal adenocarcinoma av James T. Topham, Joanna M. Karasinska, Andrew Metcalfe, Hassan A. Ali, Steve E. Kalloger, Maya Kevorkova, Emma Titmuss, Gian Luca Negri, Sandra E. Spencer, Gun Ho Jang, Grainne M. O’Kane, Richard A. Moore, Andrew J. Mungall, Jonathan M. Loree, Faiyaz Notta, Julie M. Wilson, Oliver F. Bathe, Patricia A. Tang, Rachel Goodwin, Gregg B. Morin, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Daniel J. Renouf, David F. Schaeffer

    Publicerad 2025-08-01

    Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited therapeutic options. While genome profiling has benefitted clinical decision-making in many cancer types, PDAC remains among the most lethal solid cancers and has relatively few clinically actionable molecul...

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