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    Analytical development and application of a targeted liquid chromatography-tandem mass spectrometry assay for chimeric aducanumab

    Analytical development and application of a targeted liquid chromatography-tandem mass spectrometry assay for chimeric aducanumab di Emma H. Doud, Kasi Hansen, Kathryn A. Haynes, Kierra Eldridge, Jaison Arrivalagan, Nitin Charbe, Lais Da Silva, Sara K. Quinney, Amber L. Mosley, Stacey J. Sukoff Rizzo, Paul R. Territo

    Pubblicazione 2025-12-01

    A sensitive and specific liquid chromatography-tandem mass spectrometry assay was developed for the quantification of chimeric aducanumab (chAdu), a therapeutic antibody targeting pathological amyloid plaques in Alzheimer’s disease, in murine biological matrices. This method addresses the challenges...

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