Search Results - Edwin Parra

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  1. 1
    Intratumoral neutrophil-to-lymphocyte ratio is mirrored by circulating neutrophil-to-lymphocyte ratio in non-small cell lung cancer

    Intratumoral neutrophil-to-lymphocyte ratio is mirrored by circulating neutrophil-to-lymphocyte ratio in non-small cell lung cancer by Jing Wang, Ignacio I Wistuba, Alexandre Reuben, Chantale Bernatchez, Tina Cascone, Jianjun Zhang, Boris Sepesi, Ara A Vaporciyan, Marcelo V Negrao, Hai T Tran, Lorenzo Federico, Mara B Antonoff, Stephen G Swisher, John V Heymach, Don L Gibbons, Cara L Haymaker, Lauren Byers, Edwin Parra, Younghee Lee, Daniel J McGrail, Nathaniel Deboever, Kyle G. Mitchell

    Published 2025-06-01

    Tumor-initiated emergency granulopoiesis results in expansion of the circulating neutrophil compartment and neutrophil recruitment into the tumor microenvironment (TME), which may in turn promote tumor progression. Although an elevated circulating neutrophil-to-lymphocyte ratio (cNLR) has repeatedly...

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  2. 2
    Phase II basket trial of Dual Anti-CTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) SWOG S1609: pancreatic neuroendocrine neoplasm (PNEN) cohort

    Phase II basket trial of Dual Anti-CTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) SWOG S1609: pancreatic neuroendocrine neoplasm (PNEN) cohort by Ignacio I Wistuba, Jianhua Zhang, Anup Kasi, Hong Chen, Seunghee Kim-Schulze, Holden T Maecker, Elad Sharon, Razelle Kurzrock, Sacha Gnjatic, Young Kwang Chae, Jiexin Zhang, Jianjun Zhang, Sandip Pravin Patel, Cara L Haymaker, Megan Othus, Charles Blanke, Edwin Parra, Gheath Al-Atrash, Caroline Duault, J Jack Lee, Helen X Chen, Edgar Gonzalez-Kozlova, Dzifa Yawa Duose, Luisa Solis Soto, Ganiraju Manyam, Christopher W Ryan, Jillian Fisher, Bhavana Konda, Mark Walshauser, Caddie Laberiano Fernandez, Raja Luthra, Christine M Magner

    Published 2025-06-01

    Purpose SWOG S1609 Dual Anti-CTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) studied the efficacy of ipilimumab combined with nivolumab across multiple rare tumor types. We report the results of the pancreatic neuroendocrine neoplasm (PNEN) cohort.Experimental design Treatment consisted of ipili...

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