Search Results - E. V. Mitenko

The article describes a case with a severe course of oligoarticular juvenile idiopathic arthritis with the development of contracture and destructive articular alterations. The successful use of methotrexate (15mg/m2 of body surface per week, subcutaneously) in a child with early arthritis (disease...

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The article contains a history case of early onset of pauciarticular juvenile rheumatoid arthritis resistant to standard immunosuppressive treatment with methotrexate at a dose of 15 mg/m2 per week orally, with development of contractures and destructive changes in the joints. The resistance was suc...

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The article presents a clinical case of severe systemic juvenile rheumatoid arthritis, refractory to traditional immunosuppressive treatment and with insufficient efficacy of chimeric homogenous anti-TNF-a antibodies. The patient received 2 courses of anti-Blymphocyte’s- CD20-antibodies that helped...

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A clinical case of severe juvenile scleroderma is represented in this article. The patient had a high activity and aggressive course of disease, he was resistant to steroid, cyclophosphomide and methotrexate therapy in combination with drugs, improving blood circulation. The authors describe the suc...

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This article contains observation of severe poliarticular variant of juvenile rheumatoid arthritis, resistant to glucocorticoid treatment and classic immunosuppressive therapy. There is a description of biologic treatment — with chimeriс antibodies to TNF α — infliximab in a patient with protracted...

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The article presents a case of early onset of systemic juvenile arthritis with active articular syndrome, severe systemic manifestations and high level of laboratory disease activity indicators. It describes successful use of methotrexate for intramuscular administration in the dose of 25 mg/m2 of b...

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The article presents a case report of severe course of nodular polyarteritis. The disease was highly active, aggressive, and refractory to treatment with corticosteroids and cyclophosphamide combined with plasmapheresis and drugs for microcirculation improvement. The treatment with chimerical anti-C...

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Aim: to assess efficacy and safety of abatacept usage in children and adolescents with polyarticular juvenile idiopathic arthritis without systemic manifestations. Patients and methods: 15 patients aged 13 (11; 14,5) years old were included into the study; the mean duration of disease course was 4 (...

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The article contains results of the study of efficacy and safety of adalimumab treatment given to 110 patients with juvenile idiopathic arthritis (JIA) and arthritis with eye-lesions, refractory to classical immunosuppressive treatment. Follow up period was from 3 monthsto 1 year long. The dosage re...

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This article contains results of the comparative study of rituximab and methotrexate efficacy in children with systemic juvenile idiopathicarthritis. 115 patients aged 2 to 16 years were enrolled in the study, main group consisted of 75 patients receiving rituximabe, and 40 patients in control group...

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The article offers successful application of a preparation of human monoclonal antibodies to tumor necrosis factor (TNF) α – adalimumab – in the setting of a severe course of juvenile idiopathic arthritis characterized by inefficiency of the standard antirheumatic therapy and secondary resistance to...

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This article contains results of the research of tocilizumab treatment efficacy and safety in 39 patients with severe systemic juvenile idiopathic arthritis, resistant to standard immunosuppressive treatment. Tocilizumab efficacy analysis has shown 50% of patients with inactive disease after 6 month...

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The aim of the study was to assess the efficacy and safety of etanercept treatment in combination with methotrexate in 32 patients with juvenile idiopathic arthritis and primary and secondary inefficiency of intolerance of infliximab. In 1 month after the switching to etanercept the improvement was...

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A history case of a patient with psoriatic arthritis, characterized by severe disease course, systemic symptoms, significantly increased laboratory markers, polyarticular syndrome, typical skin and nails changes, rapid development of patient’s disability and low quality of his and his family life is...

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The case of early debut and heavy course of juvenile idiopathic arthritis in the patient at the age of 1 year and 8 months, associated with uveitis refractory to the therapy by methotrexate and nonsteroid antiinflammatory preparations is presented. The given clinical example shows high therapeutic e...

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Aim: to carry out a retrospective analysis of efficacy and safety of tocilizumab treatment in children with severe resistant forms of systemic juvenile idiopathic arthritis. Patients and methods: 75 patients (35 girls and 40 boys) aged 8,8 (6; 12) years old with severe systemic juvenile idiopathic a...

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The article presents a case report of severe and prolonged polyarticular rheumatoid arthritis resistant to the treatment with classic immunosuppressive agents, nonsteroidal anti-inflammatory drugs and corticosteroids. Authors describe successful treatment with soluble receptors to TNF _ — etanercept...

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Aim: to assess efficacy and safety of hypodermic methotrexate injections in children aged from 1,5 to 16 years old with juvenile idiopathic arthritis (JIA) without extra-articular manifestations. Patients and methods: the results of treatment of 104 patients with JIA without systemic manifestations...

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The article presents a case of early onset and severe systemic form of juvenile idiopathic arthritis refractory to classical immunosuppressive therapy, including pulse therapy with methotrexate and combined therapy with methotrexate and cyclosporine. There is described the successful use of chimeric...

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Treatment of juvenile idiopathic arthritis (JIA) is one of the most important challenges in paediatric rheumatology. The results of the retrospective observational study of adalimumab (anti TNF human monoclonal antibodies) efficacy and safety in real clinical practice in treatment of 56 patients wit...

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