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    Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects

    Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects by Lingyu Wu, Yingying Wu, Shangding Yang, Siyu Jin, Qing Zhang, Zhongbin Cheng, Chaohui Wu, Yiming Hao, Ling Sun, Wenwen Liu, Donglei Shi, Jian Li, Yi-You Huang, Baoli Li, Hai-Bin Luo

    Published 2025-04-01

    Psoriasis is a chronic inflammatory disorder for which phosphodiesterase-4 (PDE4) inhibitors have emerged as promising therapeutic agents due to an ability to regulate inflammatory signaling pathways. In this study 1200 methanolic extracts from Chinese medicinal plants were screened and Eclipta pro...

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