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    BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4

    BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4 par Laura Conter, Shuchi Smita, Derrick Callahan, Shuxian Wu, Aiden Brown, Kevin M. Nickerson, Rebecca A. Elsner, Wenzhao Meng, Ayelet Peres, Gur Yaari, Steven H. Kleinstein, Eline T. Luning Prak, Wei Luo, Mark Shlomchik

    Publié 2025-07-01

    Summary: In B cells, BLIMP1 is required for plasma cell differentiation. BLIMP1 is also expressed in some germinal center (GC) B cells (GCBC), yet the role of BLIMP1 in GCBC is not understood. Here we generated mixed bone marrow (BM) chimeric mice using Prdm1+/+ CD19Cre and Prdm1fl/fl CD19Cre BM, al...

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