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    FRRS1L variants and ferriheme overload drive hyperpigmentation and systemic Iron overload in lanping black bone sheep

    FRRS1L variants and ferriheme overload drive hyperpigmentation and systemic Iron overload in lanping black bone sheep af Deping Han, Yuanyuan Zhang, Weidong Deng, Xue Yang, Jianfei Chen, Guoying Hua, Hesham Y.A. Darwish, Huaming Mao, Xiao Gou, Jiankui Wang, Kai Cui, Yuhao Ma, Yurong Tai, Xianggui Dong, Yanzhu Yao, Zu Yang, Suying Cao, Zhengquan Yu, Wansheng Liu, Xuemei Deng

    Udgivet 2025-06-01

    Abstract Background Hemoglobin metabolism disorder can result in systemic iron overload, leading to pigmentation in multiple organs. Although these disorders are often of genetic origin, the specific genes and mechanisms remain incompletely understood. Lanping black bone sheep (LP–BBS), a unique pop...

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