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    ANGPTL3 orchestrates hepatic fructose sensing and metabolism

    ANGPTL3 orchestrates hepatic fructose sensing and metabolism by Meng Zhao, Karen Y. Linde-Garelli, Zeyuan Zhang, David Toomer, Saranya C. Reghupaty, John Isaiah Jimenez, Laetitia Coassolo, Lianna W. Wat, Daniel Fernandez, Katrin J. Svensson

    Published 2025-07-01

    Summary: Fructose metabolism is linked to metabolic dysfunction-associated steatotic liver disease (MASLD), but the regulatory mechanisms governing fructose uptake remain poorly understood. Here, we demonstrate that MASLD livers exhibit increased uptake of fructose-derived carbons compared to health...

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