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    Biomimetic siRNA-METTL3 loading nanosystem alleviates myocardial hypertrophy by regulating the FASN and SCD1 m6A modification

    Biomimetic siRNA-METTL3 loading nanosystem alleviates myocardial hypertrophy by regulating the FASN and SCD1 m6A modification by Peng Teng, Xiaoyi Dai, Yuefeng Wu, Yingying Wang, Zhen Jia, Chenqiu Wang, Shixing Wang, Runhua Li, Qi Zheng, Yiming Ni, Wei Jiang, Liguo Jian, Datun Qi, Dongdong Jian, Liang Ma

    Published 2025-08-01

    RNA m6A modification plays a vital role in regulating cardiac function; however, its comprehensive mechanisms require further exploration. We observed that the expression of METTL3, a m6A methyltransferase, is significantly increased in hypertrophic hearts as well as during phenylephrine (PE)-induce...

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