Search Results - D. V. Utkin

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  1. 1
    Analysis of the Modern Methods and Means for Rapid Toxin Indication

    Analysis of the Modern Methods and Means for Rapid Toxin Indication by V. G. Germanchuk, D. V. Utkin, S. A. Shcherbakova

    Published 2012-04-01

    The risk of occurrence of emergency situations different in their character is still a pressing issue for all the states of the world's community, including the Russian Federation. Nowadays, development of the modern methods and tools for rapid toxin detection and identification holds a high po...

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  2. 2
    Application of Spectroscopy Methods for Indication and Identification of Pathogenic Biological Agents

    Application of Spectroscopy Methods for Indication and Identification of Pathogenic Biological Agents by D. V. Utkin, V. E. Kouklev, P. S. Erokhin, N. A. Ossina

    Published 2011-04-01

    The review presents data on application of UV, IR and optical spectroscopy methods for non-specific indication of pathogenic biological agents, and IR Fourier spectroscopy, and Raman spectroscopy - for their identification. Considered are advantages, disadvantages and prospects of different spectros...

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  3. 3
    CONSTRUCTION OF A DNA-MICROARRAY FOR DIFFERENTIATION BETWEEN THE MAIN AND NON-MAIN SUBSPECIES AND BIOVARS OF THE MAIN SUBSPECIES OF YERSINIA PESTIS

    CONSTRUCTION OF A DNA-MICROARRAY FOR DIFFERENTIATION BETWEEN THE MAIN AND NON-MAIN SUBSPECIES AND BIOVARS OF THE MAIN SUBSPECIES OF YERSINIA PESTIS by K. A. Nikiforov, D. V. Utkin, L. M. Kukleva, G. A. Eroshenko

    Published 2017-06-01

    Objective of the study is to design the DNA-microarray for differentiation of Y. pestis strains of the main and non-main subspecies and biovars of the main subspecies. Materials and methods. Efficiency analysis for the devised means was conducted using 62 Y. pestis strains of various subspecies and...

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  4. 4
    Biosensors: Current State and Prospects of Applying in Laboratory Diagnostics of Particularly Dangerous Infectious Diseases

    Biosensors: Current State and Prospects of Applying in Laboratory Diagnostics of Particularly Dangerous Infectious Diseases by D. V. Utkin, N. A. Ossina, V. E. Kouklev, P. S. Erokhin, S. A. Scherbakova, V. V. Kutyrev

    Published 2009-08-01

    The review presents the functional characteristics of the main types of biosensors: electrochemical, piezoelectric and optical. Shown are the examples of biosensors application for pathogenic biological agents detection. The prospects of biosensors development for laboratory diagnostics of particula...

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  5. 5
    Development of Methodological Approaches for Examination of Particularly Dangerous Infectious Diseases Agents by Means of Atomic Power Microscopy

    Development of Methodological Approaches for Examination of Particularly Dangerous Infectious Diseases Agents by Means of Atomic Power Microscopy by D. V. Utkin, O. S. Kuznetsov, P. S. Erokhin, A. N. Spitsyn, O. A. Volokh, N. A. Osina

    Published 2012-04-01

    The atomic power microscopy (APM) is used to study the cell surface structure of particularly dangerous infectious diseases agents and to carry out the morphometric analysis. APM shows similar results with scanning electron microscopy. However, its application makes it possible to avoid time-consumi...

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  6. 6
    Application of MALDI Mass-Spectrometry for Diagnostics of Particularly Dangerous Infectious Diseases: Current State of Affairs and Prospects

    Application of MALDI Mass-Spectrometry for Diagnostics of Particularly Dangerous Infectious Diseases: Current State of Affairs and Prospects by A. N. Spitsyn, D. V. Utkin, V. E. Kuklev, S. A. Portenko, V. G. Germanchuk, N. A. Osina

    Published 2014-09-01

    Mass spectrometry is a modern physical-chemical analytical method that provides for qualitative and quantitative assessment of the substance composition. It is based on pre-ionization of the atoms and molecules included into it. One of the advanced methods of ionization, due to which mass-spectromet...

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  7. 7
    Non-Specific Indication of Microorganisms in Environmental Samples

    Non-Specific Indication of Microorganisms in Environmental Samples by A. N. Spitsyn, N. A. Osina, V. G. Germanchuk, D. V. Utkin, I. N. Sharova, V. E. Kuklev, S. A. Portenko

    Published 2018-04-01

    The review presents an analysis of modern methods and instruments for performing nonspecific detection of pathogenic biological agents in environmental objects. Discussed are technological characteristics of application of these methods for the detection of biological substances of protein nature in...

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  8. 8
    MALDI-TOF Mass-Spectrometry Analysis of Plague Agent Strains

    MALDI-TOF Mass-Spectrometry Analysis of Plague Agent Strains by A. N. Spitsyn, D. V. Utkin, N. E. Shcherbakova, S. A. Portenko, A. S. Abdrashitova, I. A. Kas’Yan, V. G. Germanchuk, V. E. Kuklev

    Published 2016-06-01

    Objective of the study was to demonstrate practicability of data base creation, containing reference mass-spectra of agents of particularly dangerous infections, using MALDI-TOF mass-spectrometry, by the example of plague agent strains. Materials and methods. MALDI-TOF mass-spectrometry was deployed...

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  9. 9
    Development of an Integrated System for Molecular-Genetic Identification of <i>Yersinia pestis</i> Strains

    Development of an Integrated System for Molecular-Genetic Identification of <i>Yersinia pestis</i> Strains by K. A. Nikiforov, E. G. Oglodin, M. A. Makashova, A. N. Balykova, D. V. Utkin, L. M. Kukleva, G. A. Eroshenko, V. V. Kutyrev

    Published 2023-05-01

    The paper describes a developed comprehensive system for molecular-genetic identification of Yersinia pestis strains according to their appurtenance to certain subspecies, biovars, phylo-geographic populations, using realtime PCR (RT-PCR), allele-specific RT-PCR, and multiplex PCR with hybridization...

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  10. 10
    Improvement of Diagnostic System in a Real-Time RT-PCR “AmpliSens EBOV (ZAIRE)-FL” Format for Zaire ebolavirus RNA Detection

    Improvement of Diagnostic System in a Real-Time RT-PCR “AmpliSens EBOV (ZAIRE)-FL” Format for Zaire ebolavirus RNA Detection by V. G. Dedkov, M. V. Safonova, S. A. Bodnev, A. S. Kabanov, V. A. Safronov, A. A. Lopatin, V. E. Kuklev, D. V. Utkin, V. V. Maleev, G. A. Shipulin

    Published 2015-09-01

    Taking into consideration experience in utilization of “AmpliSens EBOV (ZAIRE)-FL” in the setting of SAET mobile laboratory complex, carried out has been the improvement of the panel with a view to elapsed time reduction and analytical sensitivity enhancement. It provides for the analytical sensitiv...

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  11. 11
    The Study of the Immune Layer to the Cholera Agent in Individuals Living in the Republic of Guinea

    The Study of the Immune Layer to the Cholera Agent in Individuals Living in the Republic of Guinea by D. V. Utkin, E. V. Naidenova, K. A. Nikiforov, A. V. Boiko, D. A. Agafonov, M. N. Lyapin, A. A. Lopatin, I. Bangoura, T. D. Camara, S. Boumbaly, M. Y. Boiro

    Published 2019-10-01

    For a reliable assessment of the presense of the immune layer to cholera agent, it is necessary to determine the level of specific antibodies in human blood serum. To detect specific anticholera antibodies serological methods are used, aimed to identify agglutinating, vibriocidal and toxin neutraliz...

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  12. 12
    Molecular-Genetic Monitoring of SARS-CoV-2 Genovariants in the Territory of the Volga Federal District of the Russian Federation. Communication 1

    Molecular-Genetic Monitoring of SARS-CoV-2 Genovariants in the Territory of the Volga Federal District of the Russian Federation. Communication 1 by N. A. Osina, Ya. M. Krasnov, N. P. Guseva, E. G. Boolgakova, I. V. Domanina, A. D. Katyshev, D. V. Utkin, O. V. Vinogradova, N. V. Kudryashov, T. A. Polunina, T. Yu. Krasovskaya, S. A. Portenko, S. A. Shcherbakova, V. V. Kutyrev

    Published 2021-04-01

    Emergence of various genovariants of the SARS-CoV-2 virus, which are characterized by a higher ability to spread and a more severe clinical manifestations compared to the initial variants, require molecular-genetic monitoring of strains circulating in the Russian Federation.The aim of the work was t...

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  13. 13
    Management and Performance of Diagnostic Investigations on the Platform of the Specialized Anti-Epidemic Team Mobile Complex During EVD Epidemics in 2014 in the Republic of Guinea

    Management and Performance of Diagnostic Investigations on the Platform of the Specialized Anti-Epidemic Team Mobile Complex During EVD Epidemics in 2014 in the Republic of Guinea by A. Yu. Popova, V. A. Safronov, N. F. Magasuba, D. V. Utkin, G. N. Odinokov, O. V. P’Yankov, A. S. Sergeev, S. A. Bodnev, A. S. Kabanov, V. E. Kuklev, A. A. Lopatin, A. S. Razdorsky, K. A. Nikiforov, S. A. Shcherbakova, V. A. Ternovoy, A. P. Agafonov, V. N. Mikheev, V. V. Kutyrev

    Published 2014-12-01

    Given is an account of the EVD epidemics that started in the Republic of Guinea in December, 2013 and spread over West African countries within 2014. Established have been the grounds for the Rospotrebnadzor SAET deployment in the Republic of Guinea, objectives, goals and stuffing of the mission, an...

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  14. 14
    Studies of Ebola Virus persistence in the Body Fluids of a Patient at Advanced Stages of Convalescence

    Studies of Ebola Virus persistence in the Body Fluids of a Patient at Advanced Stages of Convalescence by A. A. Lopatin, E. V. Naidenova, V. A. Safronov, A. S. Razdorsky, D. V. Utkin, Zh. A. Kas’Yan, A. A. Kritsky, V. A. Ternovoy, A. E. Nesterov, A. A. Sergeev, A. L. Sylla, V. . Kanomou, M. Y. Boiro, Yu. V. Demina, V. Yu. Khoroshilov, A. Yu. Popova, V. V. Kutyrev

    Published 2015-09-01

    At present EVD epidemic, which claimed the lives of more than 10000 people, is still underway in West Africa Countries. Promptness and quality of laboratory diagnostics, alongside with delivered anti-epidemic measures predetermine efficacy of Ebola response operation. Due to a lack of means for the...

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