Αποτελέσματα αναζήτησης - D. O. Shatalov

This work reflects the description of the developed professional standard «Specialist in the preparation and operation of equipment for the production of nanostructured pharmaceuticals». Formulations of the generalized labor functions are resulted, the benefit of development of the given standard, b...

Πλήρης περιγραφή

The study of the chronic toxicity of the substance «Branched oligo(hexamethylene guanidine) hydrochloride» was carried out with repeated (within 28 days) irrigation of the oral cavity of rats and rabbits. During the experiment, observations were made of the general condition and behavioral activity...

Πλήρης περιγραφή

Some existing methodologies for quantitative estimation of guanidine hydrochloride during the analysis of various samples were described. Their shortcomings impeding the implementation of the control of the monomer in the pharmaceutical substance were identified. A method for quantitative determinat...

Πλήρης περιγραφή

Objectives. Given that microorganisms can become resistant to certain groups of drugs and considering also their ability to form biofilms, the development of new drugs that are active against adapted microflora is required. This study focused on the development of a new method for the synthesis of a...

Πλήρης περιγραφή

Theoretically substantiated and experimentally determined viscosity and adhesive properties of the experimental compositions of the liquid formulation with plant extracts of Eucalyptus (evkalimin) and Echinacea purpurea (estifan). It proved that are designed mucoadhesive pharmaceutical compositions...

Πλήρης περιγραφή

Objectives. The study set out to use mathematical modeling, in particular the method of multifactorial analysis of multicriteria optimization (MAMO), in the development of a pharmaceutical product.Methods. After carrying out experimental tests based on the proposed algorithmic sequence, the obtained...

Πλήρης περιγραφή

The acquisition of resistance to the antibiotics and antibacterial agents used by microorganisms sets the task of finding new active disinfectants. It is known that compounds of the oligoguanidine class possess pronounced antibacterial properties, low toxicity, and can exhibit a prolonged biocidal e...

Πλήρης περιγραφή

Objectives. To develop a method for the microfluidic synthesis of oligohexamethylene guanidine salts in a flow-type reactor and to evaluate its effectiveness in relation to the synthesis in a traditional capacitive reactor and compare the purities of products obtained by these methods.Methods. The s...

Πλήρης περιγραφή

Objectives. Polysorbate 80 (PS80) quantification in biopharmaceutical products has always been challenging owing to its minute content, absorption to the protein backbone, lack of specific chromophoric PS80 groups, and heterogenic nature. This work is aimed at developing an express method for PS80 a...

Πλήρης περιγραφή