Search Results - D. I. Rudenko
-
1
Efficacy and safety of Viltepso® in Duchenne muscular dystrophy: review of clinical studies
Published 2024-11-01Get full textThe author presents a literature review on the safety and efficacy of antisense oligonucleotides in the treatment of Duchenne muscular dystrophy using the exon skipping method using Viltepso® (viltolarsen), the only drug of this class registered in Russia, as an example. The analysis of internationa...
Article -
2
Dynamics of the course of Duchenne muscular dystrophy in patients taking ataluren and concomitant drug and non-drug therapy
Published 2024-01-01Get full textBackground. Duchenne muscular dystrophy is a hereditary, X-linked, progressive, disabling disease. One of the possible pathogenetic methods for treating this disease is the drug ataluren, which acts at the stage of protein translation in the ribosome and makes it possible to read information from mR...
Article -
3
Analysis of clinical manifestations and diagnosis of late-onset myasthenia gravis
Published 2020-06-01Get full textIntroduction. Myasthenia gravis is one of the most common autoimmune neuromuscular diseases, the peak incidence is in the age of 20–40 years. However, studies show that throughout the world in recent decades there has been an increase in the prevalence and incidence of myasthenia gravis among older...
Article -
4
Optimization of the pre-analytical stage of material processing for histochemical examination of skeletal muscle biopsies in the diagnosis of neuromuscular diseases
Published 2019-07-01Get full textDiagnosis of neuromuscular diseases is complicated by the variety of clinical manifestations and requires the use of additional methods, an important place among which is the pathomorphological study of skeletal muscle biopsy. Despite the fact that the procedure for taking a muscle biopsy is not tec...
Article -
5
HIRAYAMA DISEASE. CLINICAL CASE AND A REVIEW OF LITERATURE
Published 2017-03-01Get full textHirayama disease is a rare neurological disease with unilateral or asymmetric bilateral distal upper limb paresis and muscle atrophy. Here the authors report a clinical case of patient with weakness of cluster muscles and distal asymmetric upper paraparesis. Taking into consideration complaints, cl...
Article -
6
Features of psychological adaptation and compensatory mechanisms in patients with severe chronic diseases
Published 2020-12-01Get full textThe aim of the study was self-regulation of behavior and other psychological aspects of adaptive-compensatory mechanisms in patients with schizophrenia and myasthenia, in comparison with a group of healthy subjects.Materials and methods. The study involved 91 people: patients with schizophrenia (N=3...
Article -
7
Clinical and diagnostic difficulties in management of patients with laminopathies
Published 2019-11-01Get full textMutations in the LMNA gene cause developing of several phenotypes, both with isolated involvement of cardiac, muscle, adipose and bone tissues, and with their combination. The dominance of cardiovascular signs in the clinical performance and false clarity in nosology definition can cause underestima...
Article