Search Results - D. A. Dibrov
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ACCP-negative rheumatoid arthritis – clinical and immunological features
Published 2022-07-01Get full textDepending on the presence of laboratory biomarkers: rheumatoid factor IgM and anti-cyclic citrullinated peptide antibodies (ACCP), “seropositive” and “seronegative” variants of rheumatoid arthritis (RA) are distinguished. Immunological subtypes differ in risk factors, immunopathogenesis, and the cou...
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New laboratory biomarkers of rheumatoid arthritis
Published 2021-05-01Get full textThe review presents data on new biomarkers for the diagnosis of rheumatoid arthritis, considers the diagnostic parameters of antibodies to carbamylated proteins, antibodies to peptidyl arginine deaminase, antibodies to homocysteinylated α1-antitrypsin, 14-3-3η, macrophage soluble scavenger receptor...
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Rheumatoid arthritis as a clinical and immunological syndrome: focus on the seronegative subtype of the disease
Published 2023-06-01Get full textRheumatoid arthritis (RA) is the most common immune mediated (autoimmune) rheumatic disease, manifested by chronic erosive arthritis and systemic internal organ damage. Currently, RA is considered as a syndrome characterized by clinical and pathogenetic heterogeneity associated with a variety of mec...
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Fibrosing arthropathy in juvenile scleroderma
Published 2021-04-01Get full textThe group of scleroderma diseases includes a number of clinical entities, the main symptom of which is skin tightening. Scleroderma is a prominent example of these diseases, characterized by excessive synthesis and deposition of collagen in organs and tissues. A patient with juvenile systemic sclero...
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Relationship of cytokine level dynamics with longterm results of early rheumatoid arthritis therapy
Published 2022-03-01Get full textThe aim of the work – to research the relationship between the dynamics of cytokine levels in the early period (the first 12 and 24 weeks) of pharmacotherapy for rheumatoid arthritis (RA) and long-term outcomes in patients with the disease.Material and methods. The analysis included 93 patients with...
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The impact of T2T therapy on the treatment of the patients with the early rheumatoid arthritis (data from OREL registry)
Published 2021-07-01Get full textAim – to analyze long-term results of intensive treatment initiated at rheumatoid arthritis (RA) onset in real clinical practice.Material and methods. 93 RA patients were included. Subcutaneous MTX was initiated at 10–15 mg per week with further dose escalation up to 20–30 mg per week. If MTX monoth...
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Anti-carbamylated protein antibodies in ACCP-negative and ACCP-positive patients with rheumatoid arthritis
Published 2024-01-01Get full textObjective. Assess the level of antibodies to carbamylated proteins (anti-CarP) and analyse the clinical and immunological associations in patients with ACCP-negative and ACCP-positive variants of rheumatoid arthritis.Materials and methods. 150 patients with a reliable diagnosis of rheumatoid arthrit...
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Biologically active additives in the 21st century: undenatured type II collagen as an example of good medical practice
Published 2020-05-01Get full textThe paper deals with an update on biologically active additives (BAAs) and emphasizes their role in normalizing and/or improving the functional status of organs and systems, including the gastrointestinal tract microflora, in reducing the risk of diseases, etc. It gives data on the consumption and t...
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Clinical features of ACPA-negative and ACPA-positive variants of rheumatoid arthritis
Published 2023-04-01Get full textThe aim of the study was to study the features of the clinical picture of the disease in patients with ACPA-negative and ACPA-positive variants of rheumatoid arthritis.Materials and methods. The study included patients with a reliable diagnosis of rheumatoid arthritis (RA) according to the criteria...
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Combination of ankylosing spondylitis with combined autoinflammatory skin lesions (clinical observation and literature review)
Published 2021-08-01Get full textWe present a clinical case of combination of axial spondyloarthritis (axSpA) and chronic recurrent skin lesions in the form of acne conglobata, hidradenitis suppurativa (HS) with fistulous tracts formation. During the diagnostic search, the following diseases were considered: HS, SAPHO syndrome (syn...
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Combination of ankylosing spondylitis with combined autoinflammatory skin lesions. Clinical case and review
Published 2020-12-01Get full textA clinical case of a patient with axial spondyloarthritis (AxSpA) and chronic recurrent skin lesions in the form of acne conglobata, suppurative hydradenitis and the formation of fistulous tracts is presented. On the example of clinical observation, a diagnostic search was described, which included...
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Depletion-restitution therapy for autoimmune rheumatic diseases. Part 1. Fundamental prerequisites and efficacy of modern treatment technologies: anti-B-cell drugs and CAR-T therap...
Published 2025-04-01Get full textThe key element in the pathogenesis of systemic autoimmune rheumatic diseases is the breakdown of immunological tolerance and the formation of a pool of autoreactive cells. This leads to uncontrolled activation of the effector arm of cellular (T-lymphocytes) and humoral (B-lymphocytes and plasma cel...
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Depletion-restitution therapy of autoimmune rheumatic diseases. Part 2. Perspectives on bispecific antibodies
Published 2025-06-01Get full textOne of the most promising approaches to depletion-restitution therapy is the development and use of drugs based on bispecific monoclonal antibodies (bsAbs). Therapeutic bsAbs are genetically engineered biological products (biologics) based on immunoglobulin molecules capable of simultaneously bindin...
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