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    Structure-Based Design of Small-Molecule Inhibitors of Human Interleukin-6

    Structure-Based Design of Small-Molecule Inhibitors of Human Interleukin-6 द्वारा Ankit Joshi, Zhousheng Xiao, Shreya Suman, Connor Cooper, Khanh Ha, James A. Carson, Leigh Darryl Quarles, Jeremy C. Smith, Madhulika Gupta

    प्रकाशित 2025-07-01

    Human Interleukin-6 (hIL-6) is a pro inflammatory cytokine that binds to its receptor, IL-6Rα followed by binding to gp130 and subsequent dimerization to form a hexamer signaling complex. As a critical inflammation mediator, hIL-6 is associated with a diverse range of diseases and monoclonal antibod...

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