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    Manganese suppresses tumor growth through hyper-activating IRE1α

    Manganese suppresses tumor growth through hyper-activating IRE1α by Ruoxi Shi, Ming Wang, Si Chen, Xinwei Hu, Xudong Zhao, Shixin Zhou, Congli Fan, Zihan Zhou, Likun Wang

    Published 2025-08-01

    Summary: IRE1α and its downstream XBP1 signal is the most conserved unfolded protein response pathway that cells utilize to combat endoplasmic reticulum stress, also known to be utilized by tumor cells to adapt to harsh environment, leading to tumor progression. Several inhibitors against IRE1α have...

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