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Design and synthesis of 3,4-seco-Lupane triterpene derivatives: targeting tumor angiogenesis and inducing apoptosis in triple-negative breast cancer by Chunyu Gao, Chunyu Gao, Hongbo Teng, Hongbo Teng, Wenxin Zhang, Wenxin Zhang, Yaru Zhao, Yaru Zhao, Chunguo Cui, Zerbo Patrice, Liyan Wang, Liyan Wang, Yan Zhao, Yan Zhao
Published 2025-07-01BackgroundDue to the lack of effective treatment methods and targeted drugs, triple-negative breast cancer (TNBC) is not only difficult to treat clinically, but also has a poor prognosis for patients. This study aims to develop novel anti-TNBC drug candidates by designing 90 derivatives of 3,4-seco-...
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