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    Adenovectored RSV prefusion glycoprotein + soluble glycoprotein combination immunization establishes persistent opsonophagocytic antibody response through IgG3

    Adenovectored RSV prefusion glycoprotein + soluble glycoprotein combination immunization establishes persistent opsonophagocytic antibody response through IgG3 by Xin Tong, Ross Blanc, Deniz Cizmeci, Hadar Malca, Jaewon Kang, Christy Comeaux, Benoit Callendret, Arangassery Rosemary Bastian, Mehak Zahoor Khan, Galit Alter, Daniel Lingwood, Ryan P. McNamara, Ryan P. McNamara

    Published 2025-07-01

    IntroductionRespiratory syncytial virus (RSV) causes significant lower-respiratory-tract disease in high-risk groups. A phase IIb trial showed that a combination vaccine of Ad26-vectored prefusion RSV F (Ad26.preF) plus soluble prefusion F protein (SpreF) was 80 % protective, yet the longevity and f...

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