Search Results - Chen-Hsiang Shen

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  1. 1
    Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain

    Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain by Young D. Kwon, Amarendra Pegu, Eun Sung Yang, Baoshan Zhang, Michael F. Bender, Mangaiarkarasi Asokan, Qingbo Liu, Krisha McKee, Bob C. Lin, Tracy Liu, Mark K. Louder, Reda Rawi, Mateo Reveiz, Andrew J. Schaub, Chen-Hsiang Shen, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola, Peter D. Kwong

    Published 2023-12-01

    The amino-acid composition of the immunoglobulin variable region has been observed to impact antibody pharmacokinetics (PK). Here, we sought to improve the PK of the broad HIV−1-neutralizing VRC01-class antibodies, VRC07-523LS and N6LS, by reducing the net positive charge in their variable domains....

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  2. 2
    In silico improvement of affinity for highly protective anti-malarial antibodies

    In silico improvement of affinity for highly protective anti-malarial antibodies by Mateo Reveiz, Prabhanshu Tripathi, Lais Da Silva Pereira, Patience Kerubo Kiyuka, Tracy Liu, Yongping Yang, Baoshan Zhang, Dorra Benmohamed, Brian G. Bonilla, Carl W. Carruthers, Jr., Marlon Dillon, Daniel Gowetski, Sven Kratochvil, Gabriella Lagos, Mariah Lofgren, Ivan Loukinov, Shamika Mathis-Torres, Andrew J. Schaub, Elizabeth Scheideman, Arne Schön, Chen-Hsiang Shen, Yevel Flores-Garcia, Fidel Zavala, Facundo D. Batista, Azza H. Idris, Robert A. Seder, Peter D. Kwong, Reda Rawi

    Published 2025-07-01

    Summary: The monoclonal antibody CIS43 preferentially binds the junctional region of Plasmodium falciparum circumsporozoite protein (PfCSP) and is highly protective in humans. Here, we develop an in silico pipeline to improve antigen-antibody interaction energies and apply it to CIS43 variants elici...

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