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    Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells

    Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells por Kaushal Baid, Sauhard Shrivastava, Jessica Luc, Daniel Richard, Jennifer A. Aguiar, Yoan Machado, Sophie-Marie Aicher, Kimberley C. Siwak, Emmanuelle V. LeBlanc, Zahed Khatooni, Kumari G. Lokugamage, Michelle N. Vu, Angelica Morgan, Arkadeb Bhuinya, Kim R. Chiok, Hai T. Nguyen, Hannah D. Stacey, Erin Scruten, Tracy Prysliak, Winfield Yim, Andrew G. McArthur, Matthew S. Miller, Heather L. Wilson, Terence Capellini, Paul A. Faure, Qiang Liu, Samira Mubareka, Vineet D. Menachery, Karen Mossman, Marcel A. Müller, Christian Drosten, Che C. Colpitts, Nolwenn Jouvenet, Christopher M. Overall, Andrew C. Doxey, Arinjay Banerjee

    Publicado 2025-07-01

    Summary: SARS-CoV-2 has caused the largest known coronavirus pandemic and is believed to have emerged from insectivorous bats. Little is known about the evolution of these viruses in their reservoir bat species. In this study, we investigate the SARS-CoV-2-host interaction using human and bat cells....

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