Search Results - Chao Xue
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Dissecting the Cellular Heterogeneity Underlying Liver Diseases Through the Integration of GWASs and Single-Cell RNA Sequencing
Published 2025-06-01Get full textLiver diseases encompass a wide range of etiologies and involve highly heterogeneous cellular environments, yet the specific cellular states through which genetic risk contributes to disease remain incompletely understood. In this study, we integrated genome-wide association study (GWAS) data from s...
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The potential of olfaction loss to induce cognitive impairment and anxiety behavior in mice via the microbiota-gut-brain axis
Published 2025-07-01Get full textIntroductionOlfactory dysfunction and cognition decline are frequently observed; however, very little is known about whether olfactory disorders trigger cognitive impairment.MethodsHere, we induced olfactory loss in mice and investigated whether and how olfactory loss induces cognitive impairment an...
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Super‐Heterostructures of Twisted Pd Nanoarrays Epitaxially Grown on Chiral Au Nanorods Boost Circularly Polarized Photocatalysis
Published 2025-07-01Get full textAbstract Seed‐mediated growth provides an efficient way to produce chiral hybrid nanocrystals, mainly benefitting from the recent successful synthesis of discrete chiral metal nanocrystals. However, the chiroptical response of chiral core‐shell nanostructures decreases rapidly when the functional la...
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Anticancer Quinolinol Small Molecules Target Multiple Pathways to Promote Cell Death and Eliminate Melanoma Cells Resistant to BRAF Inhibitors
Published 2025-06-01Get full textSmall molecule inhibitors that target the E3 ligase activity of MDM2-MDM4 have been explored to inhibit the oncogenic activity of MDM2-MDM4 complex. MMRi62 is a small molecule that was identified using an MDM2-MDM4 E3 ligase-based high throughput screen and a cell-death-based secondary screen. Our p...
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