Search Results - Chao Cheng
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Promotion of HIV clearance by sensitization of HIV reservoirs to cell death
Published 2025-07-01Get full textIntroductionHIV integrates its proviral DNA into the host genome to establish persistent infection. To promote HIV clearance, we have designed an approach for selective elimination of host cells harboring replication-competent HIV (SECH), through inhibition of autophagy and anti-apoptotic molecules...
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Integrative Analysis Reveals the Prognostic Effects of Epigenetic Regulators in Bladder Cancer
Published 2025-07-01Get full textABSTRACT Background Epigenetic regulatory genes (epiRG) are pivotal in the epigenetic regulation of the human genome, primarily through DNA and histone modifications. These genes are frequently mutated in human cancers, particularly bladder cancer (BC). However, the functional impact of epiRG mutati...
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Oral microbiota and central nervous system diseases: A review
Published 2025-03-01Get full textAbstract Oral microbiota is the second largest microbial colony in the body and forms a complex ecological community that influences oral and brain health. Impaired homeostasis of the oral microbiota can lead to pathological changes, resulting in central nervous system (CNS) diseases. However, the m...
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Iridoids derived from Valeriana jatamansi Jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signali...
Published 2025-07-01Get full textBackgroundValeriana jatamansi Jones, a globally utilized medicinal plant, exhibits favorable pharmacological effects against depression and tumors. Iridoids derived from V. jatamansi (IRFV) promote recovery following spinal cord injury (SCI). Inflammation and disruption of the blood-spinal cord barr...
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Advancing liver cancer treatment with dual-targeting CAR-T therapy
Published 2025-06-01Get full textAbstract Chimeric antigen receptor (CAR)-T cell therapy targeting glypican-3 (GPC3) has shown promise in the treatment of hepatocellular carcinoma (HCC). However, the efficacy of CAR-T cells that focus solely on cell surface tumor-associated antigens is often limited. To overcome this challenge, we...
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