Risultati della ricerca - Changming Yu

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  1. 1
    Characterization of an mRNA-Encoded Antibody Against Henipavirus

    Characterization of an mRNA-Encoded Antibody Against Henipavirus di Zixuan Liu, Bingjie Sun, Ting Fang, Xiaofan Zhao, Yi Ren, Zhenwei Song, Sijun He, Jianmin Li, Pengfei Fan, Changming Yu

    Pubblicazione 2025-07-01

    Nipah and Hendra viruses are lethal zoonotic pathogens with no approved vaccines or therapeutics. mRNA produced via in vitro transcription enables endogenous protein expression and cost reduction. Here, we systematically screened natural and artificial untranslated regions (UTRs) and identified an o...

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    Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

    Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein di Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu

    Pubblicazione 2025-07-01

    Abstract Hendra and Nipah viruses (HNVs), zoonotic paramyxoviruses with >50% case fatality rates, cause fatal encephalitis and respiratory disease, yet lack approved therapies. Here, nine rhesus‐derived monoclonal antibodies (mAbs) targeting the fusion glycoprotein (F) prefusion conformation are...

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