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    Immune microenvironment heterogeneity characterizes biologically distinct KRASmut/SPOPmut and KRASmut/PIK3CAmut mesonephric-like adenocarcinoma subtypes revealed by integrated whole-exome and transcriptomic profiling

    Immune microenvironment heterogeneity characterizes biologically distinct KRASmut/SPOPmut and KRASmut/PIK3CAmut mesonephric-like adenocarcinoma subtypes revealed by integrated whol... by Jing Zeng, Jing Zeng, Qingli Li, Qingli Li, Kemin Li, Kemin Li, Lu Yang, Lu Yang, Lian Xu, Lian Xu, Wei Wang, Wei Wang, Kaixuan Yang, Kaixuan Yang, Qingbo Wei, Jin Wang, Changbin Zhu, Rutie Yin, Rutie Yin

    Published 2025-07-01

    ObjectiveThis study aims to uncover the molecular biology and immune microenvironment of gynecological mesonephric-like adenocarcinoma (MLA).MethodsTo determine the comprehensive characteristics of MLA, 17 patients with MLA were retrospectively enrolled in this study. Whole-exome sequencing and mRNA...

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