תוצאות חיפוש - Brian Carr

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  1. 1
    HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys.

    HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys. מאת Brian Moldt, Abishek Chandrashekar, Erica N Borducchi, Joseph P Nkolola, Heather Stephenson, Mark Nagel, Magdeleine Hung, Joshua Goldsmith, Craig S Pace, Brian Carr, Nathan D Thomsen, Wade S Blair, Romas Geleziunas, Dan H Barouch

    יצא לאור 2022-04-01

    A key challenge for the development of a cure to HIV-1 infection is the persistent viral reservoir established during early infection. Previous studies using Toll-like receptor 7 (TLR7) agonists and broadly neutralizing antibodies (bNAbs) have shown delay or prevention of viral rebound following ant...

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  2. 2
    Identification and engineering of potent bispecific antibodies that protect against herpes simplex virus recurrent disease

    Identification and engineering of potent bispecific antibodies that protect against herpes simplex virus recurrent disease מאת Chingwei V. Lee, Hector Viadiu, Apurva Kalamkar, David I. Bernstein, Andrew Pae, Xinchao Yu, Sylvia Wong, Fernando J. Bravo, Sheng Ding, Elbert Seto, Magdeleine Hung, Yu Yu, Weimei Xing, Giuseppe A. Papalia, Wei Kan, Brian Carr, Majlinda Thomas, Leah Tong, Priyanka Desai, Nadine Jarrousse, Alexandre Mercier, Meghan M. Holdorf, Simon P. Fletcher, Emma Abernathy

    יצא לאור 2025-08-01

    Summary: Herpes simplex virus (HSV) causes lifelong infections, including oral and genital herpes. There is no vaccine, and current antivirals are only partially effective at reducing symptoms and transmission. Therapeutic antibodies offer a potentially long-acting treatment option, although efforts...

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