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    Demethylzeylasteral inhibits proliferation and metastasis of osteosarcoma cells by modulating the PI3K/AKT/Autophagy pathways

    Demethylzeylasteral inhibits proliferation and metastasis of osteosarcoma cells by modulating the PI3K/AKT/Autophagy pathways by Xuhui Yuan, Jiayu Li, Bo Yu, Feng Cai, Binqi Chen, Jun Liu, Yuanxiang Peng, Duo Zeng, Qi Liao, Lang Liu

    Published 2025-08-01

    Background: Osteosarcoma (OS) remains a highly aggressive malignancy with limited treatment options, necessitating the discovery of novel therapeutic agents. Demethylzeylasteral (DEM), a compound previously shown to exert anti-tumor properties in several malignancies, has not been sufficiently explo...

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