Search Results - Bin YU

Molecular editing around privileged scaffolds, also known as periphery editing, is a commonly used strategy in contemporary drug discovery and development. Tranylcypromine (TCP) is a widely acknowledged scaffold with diverse pharmacological activities. TCP-derived compounds target different enzymes...

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The SQUAMOSA promoter binding protein (SBP)-box genes encode a kind of plant-specific transcription factors (TFs) and play important roles in the regulation of plant development. In this study, a genome-wide characterization of this family was conducted in maize (Zea mays). Thirty-one SBP-box genes...

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Non-peptide macrocyclic drugs possess unique structural advantages that allow them to target various biomolecules of interest and thus show therapeutic potential against various diseases such as cancer, infectious diseases, etc. This review article examines 34 non-peptide macrocyclic drugs approved...

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BackgroundThe interplay between gynaecological surgeries and arthritis pathogenesis remains poorly understood. This study offers new insights into potential health risks associated with post-hysterectomy.MethodsThe cross-sectional study utilized data from the National Health and Nutrition Examinatio...

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In this paper, a new short reference differential chaos shift keying (SR-DCSK) cooperative communication system based on modified code index modulation, referred to as the MCIM-SR-DCSK-CC system, is proposed. In the proposed MCIM-SR-DCSK-CC system, the information bits are transmitted to both the re...

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BackgroundHyperuricemia is a recognized predictor of hypertension. However, the consistent link between elevated serum uric acid (SUA) levels and hypertension risk across different age groups, especially in males, remains a subject of debate. This study aimed to examine the association between SUA t...

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Single-molecule localization methods play a vital role in a localization-based super-resolution fluorescence microscopy. However, it is difficult for conventional localization schemes based on the Gaussian fitting to locate overlapped high-density fluorescent emitters. Currently, in the spatial doma...

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<h4>Purpose</h4>It remains controversial whether mini-incision (MI) benefits patients in total hip arthroplasty (THA). We performed a meta-analysis of randomized controlled trials (RCTs) to assess the effects of MI on surgical and functional outcomes in THA patients.<h4>Methods<...

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Background: Emerging evidence indicates a potential association between aberrant expression of GIPC PDZ Domain Containing Family member 2 (GIPC2) and the progression of colorectal cancer (CRC). However, the detailed characteristics of GIPC2 expression and its prognostic implications in CRC remain to...

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Modular multiplication is a pivotal operation in public-key cryptosystems such as RSA, ElGamal, and ECC. Modular multiplication design is crucial for improving overall system performance due to the large-bit-width operation with high computational complexity. This paper provides a classification of...

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IntroductionSuperficial esophageal squamous cell carcinoma (SESCC) is defined as neoplastic lesions limited to the mucosa or submucosa regardless of the nodal status. The infiltrative growth pattern (INF) has been implicated in tumor aggressiveness and prognosis in various cancers, but the applicati...

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Mutants on stalk strength are essential materials for the studies on the formation of plant cell wall. In this study, a brittle stalk mutant of maize, designated as Bk-x, was screened from a Mutator inserted mutant library. At the germination and early seedling stage, the mutant plants were indistin...

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<h4>Background</h4>As an anti-aging protein, although studies increasingly suggest that the Klotho plays a role in the auditory system, the link between serum Klotho levels and tinnitus remains poorly characterized. The aim of this study was to investigate the associations between serum...

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BackgroundPrevious studies primarily focused on advanced-stage gastric cancer have identified significant differences between gastric cardiac cancer (GCC) and gastric non-cardiac cancer (GNCC) in clinical, pathological, and molecular phenotypes. This study focuses on early-stage GCC and GNCC cases t...

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To investigate the role of potassium in the regulation of potato growth, dynamic changes in starch–sugar metabolism, and processing quality. In this study, “Gannong Potato No. 9” was used as the test material, and five potassium concentration treatments of 0, 9.4, 23.5, 28.5, and 37.6 mmol/L were se...

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PRRSV continues to evolve, complicating its epidemiological landscape in China. In this study, we isolated a novel PRRSV strain, GZ2022, from a swine farm in Guizhou Province. Subsequent analyses performed on this isolate included complete genome sequencing, phylogenetic analysis, recombination asse...

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Hydraulic legged robots, with advantages such as high load capacity and power density, have become a strategic driving force in advancing intelligent mobile platform technologies. However, their high energy consumption significantly limits long-duration endurance and efficient operational performanc...

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Abstract While the concept of high entropy has gained prominence in materials design, disentangling specific impacts of entropy on material properties from the enthalpy of mixing remains elusive. It is demonstrated that the role of entropy can be distinguished from the dynamics of glass‐forming liqu...

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