Search Results - Benjamin Lin

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  1. 1
    Xenoline-polarized macrophages as an alternative in vitro model of tumor-associated macrophages in glioblastoma

    Xenoline-polarized macrophages as an alternative in vitro model of tumor-associated macrophages in glioblastoma by Hasan Alrefai, Benjamin Lin, Amr Elkholy, Manoj Kumar, Taylor L. Schanel, Kevin J. Lee, Patricia H. Hicks, Joshua C. Anderson, Gao Guo, Eun-Young Erin Ahn, C. Ryan Miller, Christopher D. Willey

    Published 2025-06-01

    Abstract Tumor-associated macrophages (TAMs) are the most abundant non-cancerous cell type in glioblastoma (GBM) and heavily influence GBM biology, contributing to tumor progression, therapeutic resistance, immune evasion, and neovascularization. Current in vitro models that utilize IL-4/IL-13 stimu...

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  2. 2
    Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma

    Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma by Benjamin Lin, Abigail K. Shelton, Erin Smithberger, Julia Ziebro, Kasey R. Skinner, Ryan E. Bash, Richard Kirkman, Allie Stamper, Madison Butler, Alex Flores, Steven P. Angus, Michael P. East, Timothy F. Cloughesy, David A. Nathanson, Michael E. Berens, Jann N. Sarkaria, Zev A. Binder, Donald M. O’Rourke, Timothy C. Howton, Brittany N. Lasseigne, Christopher D. Willey, Gary L. Johnson, Anita B. Hjelmeland, Frank B. Furnari, C. Ryan Miller

    Published 2025-06-01

    Abstract GBM is an aggressive primary malignant brain tumor that has a poor prognosis. Molecular characterization of GBM has shown that EGFR mutations are present in over 50% of tumors. However, EGFR inhibitors have not shown clinical efficacy in contrast to other EGFR-driven neoplasms due to the un...

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