Search Results - B. I. Geltser

Precise mechanisms of tolerance loss to thyroid auto-antigens are still largely unknown, thus preventing further elucidation of key pathogenetic stages in autoimmune diseases affecting thyroid gland, and, therefore, to identify target pathways for treatment of these disorders. Detailed studies on th...

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Pathogenesis studies in thyroid autoimmune diseases take a specific place among endocrine disorders, due to high prevalence of these pathologies, thus representing an urgent problem of the modern medicine. Their triggering mechanisms of their are still unknown. Changes of thyroid status in cases of...

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Aim. To evaluate arterial stiffness and 24-hour blood pressure (BP) profile in breast cancer (BC) in women with normotension, masked hypertension (MH) and primary hypertension (HTN) before and after chemotherapy (CT) with a combination of doxorubicin and cyclophosphamide.Material and methods. The st...

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Aim. To evaluate cardiometabolic risk (CMR) factors in women with breast cancer (BC) before and after chemotherapy (CT) with doxorubicin and cyclophosphamide.Material and methods. This prospective cohort study included 154 women with a median age of 43 years with newly diagnosed stage IIA-IIIB BC. T...

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The review discusses an analysis of the literature on various aspects of the pathogenesis, diagnosis and treatment of vasospastic angina (VA). Data on the prevalence of coronary artery spasm (CAS) in various populations, as well as risk factors and triggers, are presented. We considered pathophysiol...

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Machine learning (ML) is among the main tools of artificial intelligence and are increasingly used in population and clinical cardiology to stratify cardiovascular risk. The systematic review presents an analysis of literature on using various ML methods (artificial neural networks, random forest, s...

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Machine learning (ML) are the central tool of artificial intelligence, the use of which makes it possible to automate the processing and analysis of large data, reveal hidden or non-obvious patterns and learn a new knowledge. The review presents an analysis of literature on the use of ML for diagnos...

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Aim. To assess the use of isosorbide-5-mononitrate in clinical practice and evaluate its benefits in antianginal therapy of stable angina pectoris, based on pharmaco-economic analysis data. Material and methods. The authors analysed 902 medical histories of in-patients treated in a cardiology depart...

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The review presents an analysis of publications on use of machine learning (ML) to assess the pretest probability of obstructive and non-obstructive coronary artery disease (CAD). Data on the high prevalence of non-obstructive CAD among patients referred for coronary angiography are presented, which...

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Respiratory muscle (RM) strength was studied in 85 men with exacerbations of chronic obstructive pulmonary disease (COPD). The strength indicators of expiratory (MEP) and inspiratory pressure (MIP, SNIP) in oral cavity were registered by means of the MicroRPM device (CareFusion, UK), as well as intr...

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Aim. To evaluate the predictive potential of complete blood count (CBC) and coronary involvement parameters for predicting inhospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).Material and methods. This single-center...

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The review presents an analysis of the scientific literature on comorbidity of coronary artery disease (CAD) and assessment of its impact on the results of coronary artery bypass grafting (CABG). Arterial hypertension (AH), chronic obstructive pulmonary disease (COPD), metabolic syndrome (MS), and d...

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Aim. To assess the hemodynamic status by transpulmonary thermodilution (TPTD) in patients with ischemic heart disease (IHD) with different comorbidities before and after coronary artery bypass grafting (CABG).Materials and methods. 66 patients with IHD (40 men and 26 women) aged 53 to 77 years who w...

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Aim. To assess the effects of various antianginal nitrate therapy variants on quality of life (QoL) in patients with chronic coronary heart disease (CHD). Material and methods. In total, 259 patients were examined: 153 males (59,1 %) and 106 females (40,9 %); mean age 62,6±3,4 years. All participant...

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Aim. To develop an algorithm for selecting predictors and prognosis of atrial fibrillation (AF) in patients with coronary artery disease (CAD) after coronary artery bypass grafting (CABG).Material and methods. This retrospective study included 886 case histories of patients with CAD aged 35 to 81 ye...

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Aim. To develop predictive models of obstructive coronary artery disease (OPCA) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) based on the predictive potential of cardiometabolic risk (CMR) factors.Material and methods. This prospective observational cohort study inclu...

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Aim. Assessment of lung volume status and oxygen transport system in patients with coronary artery disease (CAD) with different clinical types of comorbidity before and after coronary artery bypass grafting (CABG).Material and methods. The observational controlled study included 66 patients with CAD...

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Aim. To evaluate the predictive potential of the parameters of complete blood count (CBC), lipid profile and their ratios for predicting obstructive coronary artery disease (oCAD) in patients with non-ST elevation acute coronary syndrome (NSTEACS).Material and methods. The study included 600 patient...

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Aim. To assess the relationship of cardiometabolic risk factors in patients with various phenotypes of masked hypertension (MH).Material and methods. The study included 207 men with a median age of 34,6 years [32,3; 36,3] being systematically stressed. All examined patients had normal clinical blood...

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Osteomyelitis of the lower jaw is one of the urgent problems of modern medicine. There are many reasons for the evolvement of purulent necrotic processes of the jaw bones, including the role of disorders in the systems of innate and adaptive immunity. The aim of the study was to determine the conten...

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