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    A multicomponent reaction-initiated synthesis of imidazopyridine-fused isoquinolinones

    A multicomponent reaction-initiated synthesis of imidazopyridine-fused isoquinolinones by Ashutosh Nath, John Mark Awad, Wei Zhang

    Published 2025-06-01

    A new synthetic route initiated with Groebke–Blackburn–Bienaymé (GBB) followed by N-acylation, intramolecular Diels–Alder (IMDA), and dehydrative re-aromatization reactions for the synthesis of imidazopyridine-fused isoquinolinones is developed. Gaussian computation analysis on the effect of the sub...

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