Zoekresultaten - Andrea Califano
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Reverse engineering neuron-type-specific and type-orthogonal splicing-regulatory networks using diverse cellular transcriptomes
Gepubliceerd in 2025-07-01Volledige tekstSummary: Cell-type-specific alternative splicing (AS) enables differential gene isoform expression between diverse neuron types with distinct identities and functions. Current studies linking individual RNA-binding proteins (RBPs) to AS in a limited number of neuron types underscore the need for hol...
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Systematic identification and targeting of master regulator checkpoints (MRC) governing tumor microenvironment-mediated immune evasion
Gepubliceerd in 2025-06-01Volledige tekstAbrogating the immunoevasive role of the tumor immune microenvironment (TIME) represents a critical yet still elusive challenge in cancer treatment. Progress in this area has been hampered by both technological limitations and incomplete understanding of TIME-dependent immunoevasion mechanisms. We h...
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Protocol for automated graph-based clustering of single-cell RNA-seq data with application in mouse intestinal stem cells
Gepubliceerd in 2025-09-01Volledige tekstSummary: We present a protocol for isolating highly purified crypt epithelial cells from the mouse intestine for single-cell RNA sequencing (scRNA-seq). Optimized for the mouse jejunum, it can be adapted to all intestinal tracts, including the colon. The pipeline incorporates automated community det...
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