Search Results - Ana Sanchez-Azofra

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  1. 1
    Obstructive sleep apnea severity and pathophysiological traits in overlap syndrome: Insights from the SNOOzzzE cohort

    Obstructive sleep apnea severity and pathophysiological traits in overlap syndrome: Insights from the SNOOzzzE cohort by Janna Raphelson, Ana Sanchez‐Azofra, Jeremy E. Orr, Gabriela Parra, Lana McGinnis, Alexis Salinas, Steven Luu, Scott A. Sands, Ali Azarbarzin, Robert L. Owens, Jose M. Marin, Atul Malhotra, Christopher N. Schmickl

    Published 2025-07-01

    Abstract The overlap syndrome (OVS), defined as coexisting chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), is linked to worse outcomes than either condition alone. Patients with COPD and OSA may have fewer obstructive events, but underlying mechanisms remain unclear....

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  2. 2
    Adaptive PRKAA1 variant in Andeans is associated with improved ventilation and sleep phenotypes

    Adaptive PRKAA1 variant in Andeans is associated with improved ventilation and sleep phenotypes by Elijah S. Lawrence, Wanjun Gu, Mitchell C. Kong, Santiago Fassardi, Cecilia Anza-Ramirez, Esteban A. Moya, Erica C. Heinrich, James J. Yu, Jeremy E. Orr, Steven Y. Cao, Ana Sanchez-Azofra, Amy M. Cole, James E. Hall, Andrew Lin, Pamala N. DeYoung, Gustavo Vizcardo-Galindo, Jose-Luis Macarlupu, Rómulo Figueroa-Mujíca, Daniela Bermudez, Noemi Corante, Gianpiero L. Cavalleri, Eduardo Gaio, A. Mark Evans, Frank L. Powell, Atul Malhotra, Rany M. Salem, Francisco C. Villafuerte, Tatum S. Simonson

    Published 2025-08-01

    Summary: Highland groups have adapted to the extreme selective pressures of hypoxia at high altitude via alterations in the oxygen-transport cascade. PRKAA1, which encodes the catalytic subunit of the AMP-activated protein kinase (AMPK), is a notable target of natural selection in Andeans and has be...

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