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    A 3D tumor spheroid model with robust T cell infiltration for evaluating immune cell engagers

    A 3D tumor spheroid model with robust T cell infiltration for evaluating immune cell engagers by Hin Ching Lo, Hana Choi, Kevin Kolahi, Samantha Rodriguez, Leiru Gonzalez, Felix Chu, Aditee Shrotre, Xi Zhao, Aloma L. D’Souza, Ron Ferrando, Somdutta Roy

    Published 2025-08-01

    Summary: A strong interest in drugs targeting the tumor microenvironment (TME) necessitates new experimental systems that incorporate key TME components. Compared to traditional 2D cell lines, 3D ex vivo spheroids from patient-derived xenograft (PDX) materials may better capture patient tumor charac...

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