Search Results - A.H. Jan Danser

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    Disruption of cell-intrinsic PCSK9 enhances the antitumor efficacy of CD8+ T cells

    Disruption of cell-intrinsic PCSK9 enhances the antitumor efficacy of CD8+ T cells by Zhe Xu, Xiaohui Zhang, Bing Liu, Si Chen, Li Yu, Long Xu, Yiwen Yan, Letong Cai, Chengzhou Mao, Yudan He, Lizhong Liu, FuSheng Wang, A.H. Jan Danser, Xifeng Lu, Shaojun Xing

    Published 2025-07-01

    Background Tumor-derived proprotein convertase subtilisin/kexin type 9 (PCSK9) facilitates tumor progression, but the role of immune cell-intrinsic PCSK9 in tumor control remains unclear.Methods Orthotopic models of pancreatic cancer and melanoma in Pcsk9-deficient mice were established and tumor-in...

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