Search Results - A. V. Stepanov

Article presents the forecast of international migration flows for European part of Russia made by using system-dynamic approach of mathematical modeling. Forecast based on condition that dynamics of Russian economy will contain to grow as well as during retrospective period.

The search for domestic publications on this publication was conducted in the database on the RSCI website, and foreign ones in the PubMed and Google Scholar databases in the period 2022-2023. Their analysis showed that actively studied approaches to the immunocorrection of sepsis are aimed at chang...

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Purpose. To conduct an experimental and clinical study of a hypotensive effect of implantation of an improved carbon drainage with an optimized sorption capacity. Material and methods. The study involved the eyes of 50 Chinchilla rabbits divided into 3 groups, depending on the diameter of the draina...

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Objective of the study was to optimize technological scheme for the production of preparation for gene diagnostics of plague with hybridization-fluorescent registration (HFR) of results, which is associated with the assessment and selection of synthesis conditions and method of oligonucleotide probe...

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The investigations carried out resulted in the improvement of technology of synthesis of the oligonucleotide primers, components of the PCR test systems produced in the RARI Microbe. The final product output was demonstrated to increase by 93 % when 25 % aquatic ammonium solution was used for ammono...

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Objectives. The purpose of this work was to create an effective iterative algorithm for the tomographic reconstruction of objects with large volumes of initial data. Unlike the convolutional projection algorithm, widely used in commercial industrial and medical tomographic devices, algebraic iterati...

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Objective of the study is to investigate the impact of activator, oxidize, and unblocking solution on the quantitative yield of oligonucleotides during manufacturing of the test-system for Vibrio cholerae (ctxA+) DNA detection “GenChol”, using polymerase chain reaction.Materials and methods. The sub...

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Immunotherapy is the most rapidly evolving field in clinical malignant hematology. Targeting of the B-lineage surface antigen CD19 in B-lineage acute lymphoblastic leukemia and B-cell lymphoma is a story of great success. Recently two approaches of CD19 immunotargeting were approved for clinical app...

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Search for drugs efficient in prophylaxis and treatment of dangerous infections (especially arboviral ones) is rather actual, since no specific therapy is available. Many-year investigations of interferon inductors showed that they had immunomodulating, antiviral and antiinflammatory effects and wer...

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Impaired cardiovascular function in metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) is not adequately studied, and data on changes in electrocardiogram (ECG) parameters, including in rodent models of MS and T2DM, are contradictory and ambiguous.   Aim of the study was to investigate ECG...

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X-ray diffraction analysis by Rietveld method was carried out for ceramic samples of the system (1-x)BiScO3·xPbTiO3·yMnO2, х=0.63, and y=0.0017 and 0.0118. It was shown that they consist of two phases: tetragonal phase (space group P4mm) and monoclinic phase (space group Cm). The temperature depende...

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Purpose: Show the results of treatment of secondary glaucoma after severe eye burns.Methods: We observed 70 patients (108 eyes) with severe burns the eyes and their consequences, secondary glaucoma was observed in 40 patients (58 eyes). All patients with secondary glaucoma received traditional antih...

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Aim. To reveal the role of a “youth protein” GDF11 in regulation of lipid metabolism and cardiovascular system work in essential hypertension (EH) in women taking antihypertension medications and regularly involved in moderate physical exercises (kinesitherapy).Material and methods. In all participa...

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Background. Existing data regarding electrocardiographic changes in rat models of metabolic syndrome are incomplete and contradictory.The aim. Study of electrocardiogram (ECG) parameters in rats in the sucrose model of metabolic syndrome.Materials and methods. Experiments were performed on male Wist...

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Aim of case presentation. To demonstrate the course of inflammatory and sclerosing variant of the Crohn’s disease, complicated by severe nutritional failure. Nonetheless good therapeutic response was achieved at combined anti-cytokine therapy with immunosuppressive drugs and adequate nutritional sup...

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Put forward are two alternatives of a new method for optimization of conditions of LPS obtaining and purification from Y. pestis strains; as well as for avoiding application of poisonous and hard-to-remove reagents; for simplification and cost-cutting of the technique; and for rationalization of pro...

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Aim.  This paper is aimed at presenting the materials of clinical observations associated with diagnosing rare-occurring ruptures of the right dome of the diaphragm that have been overlooked for a long period.Results.  A 61-year-old man was admitted to hospital with a diagnosis of chronic heart fail...

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Fully sequenced have been glycoprotein-G, sha-psi region, as well as H-end site of the L-gene in the rabies virus strain “Moscow 3253”. Compared are amino acid sequences of proteins of “Moscow 3253” strain and other fixed strains of the virus. Established is 98 % DNA homology with RV-97, and 91% hom...

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