Search Results - A. V. Pinchuk

Up-to-date potential of individualized immune suppression therapies.

Rabbit anti-thymocyte immunoglobulin, Thymoglobulin, was first obtained over 25 years ago and currently it is the most widely used antilymphocytic immunoglobulin in solid organ transplantation. Thymoglobulin interacts with a broad range of surface antigens of T-lymphocytes, natural killer cells, B-l...

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The review reflects the history of pancreas transplantation (PT), which is closely associated with transplantation of other organs. It covers its main stages and calls the names of outstanding surgeons who have made a considerable contribution to the evolution of PT.

Background. The main controversial technical issues of pancreas transplantation are kinds of diverting pancreatic secret from the transplanted organ, as well as methods of its arterial reconstruction to ensure adequate and full blood supply of the graft. The article describes our experience in intro...

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About 2,400 pancreas transplantations are performed every year worldwide, mainly pancreaticoduodenal  transplantations. Most clinics use the classical revascularization technique using a Y-shaped vascular prosthetic implant. However, it is not always possible to restore full blood supply to the graf...

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In this report, we reflected a clinical case of the course of the proliferative stage of diabetic retinopathy in a patient suffering from type 1 diabetes mellitus (DM) and end-stage diabetic nephropathy (DN) before and after simultaneous pancreas and kidney transplantation. As a result of successful...

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The authors attempt to summarize views of leading russian experts in bioethics and medical deontology on the moral and ethical issues related to the development of the concept of brain death and its application in modern medicine. A variety of ethical issues associated with the use of the concept of...

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Introduction. Kidney transplantation is the main high-tech type of medical care aimed at saving the life of a patient with chronic kidney disease in the terminal stage of the disease. The amount of economic costs for the treatment of patients with chronic renal failure depends on the results of tran...

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The choice of immunosuppressive therapy is determined by the degree of sensitization to the histocompatibility gene complex on chromosome 6 (HLA). The risk of rejection in the early periods after surgery  increases for the patients with repeated kidney transplantation. Optimizing immunosuppressive t...

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Case report represents two episodes of procalcitonin elevation in dynamics, connected with different induction mechanisms of this sepsis marker at the patient after combined pancreas and kidney transplantation.

The emergence of new immunosuppressants, such as the macrolide drug tacrolimus (prograf), has recently become one of the most important advances in transplantology. Tacrolimus belongs to calcineurin inhibitors and differs from cyclosporine in a rapider and uniform bile acid-independent absorption, c...

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Introduction: The expansion of the criteria for donor organ retrieval contributes to an increase in the number of kidney transplantations to elderly recipients; but in view of reduced requirements to donor organ quality, a further analysis of transplantation outcomes is needed. The aim was to analyz...

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This paper describes the observation of 47 patients suffering from various kidney diseases and related metabolic syndrome. The evaluation of disorders of metabolic changes is carried out and a set of preventive measures including the use of non-drug means (not smoking, diet, physical rehabilitation)...

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The clinical example illustrates the use of microdialysis techniques for assessing function of the kidney allotransplantat in the early postoperative period. Microdialysis allows to evaluate metabolic changes in the interstitial space of the graft in real-time mode.

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The paper presents the renoprotective properties of sevoflurane and propofol in kidney transplantation. In order to study these properties microdialysis technology was used. The study included 40 patients. The patients were randomized in two groups. Sevoflurane had more effective renoprotective prop...

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Diabetes mellitus is a serious health problem in both developed and developing countries. It is expected that by 2040 the incidence of diabetes mellitus in the world will increase to 642 million people. With the increase in the incidence of diabetes mellitus, the incidence of diabetic vascular compl...

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One of the most relevant issues of nephrology, neurology, and cardiology is the management and treatment of patients with chronic kidney disease and stroke. Patients with chronic kidney disease have a risk of both thrombotic complications and bleeding, and they have a high risk of both ischemic and...

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The purpose of this study was to investigate the occurrence of HLA and MICA antibodies in patients from the waiting list for kidney transplantation and their influence on the course of post-transplant period. Determination of HLA antibodies class I and II, and MICA antibodies was performed on a plat...

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