Search Results - A. V. Gordeev

There have been now prerequisites for changing the scientific view of the etiology and pathogenesis of spondyloarthritis (SpA). An important role is assigned to the dysfunction and disintegration of the so-called barrier organs that make protection of man between his internal milieu and the environm...

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As of now, impaired immune homeostasis of the intestinal mucosa in genetically predisposed individuals is considered to be one of the major components in the pathogenesis of spondyloarthritis (SpA), which leads to systemic chronic inflammation. The results of recent studies may suggest that the inte...

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The article considers the current state of the problem related to fever of unknown origin (FUO). It highlights the main stages of studying this issue with a detailed description of the classification diagnostic criteria, etiological types, and clinical signs of certain types of FUO, which have under...

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Literature review presents the data of recent scientific studies aimed to analyze the impact of cigarette smoking on the risk of rheumatoid arthritis (RA). It is shown the main mechanisms of interaction between genetic constitution, synthesis of RA-specific antibodies, and other immune trait under t...

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Assessing the status of a patient with rheumatoid arthritis allows one to obtain information necessary to choose appropriate management tactics for the patient. The use of quantitative methods in routine practice to determine inflammatory activity is the basis for the development of standardized pat...

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The undoubted and legitimate interest of investigators in comorbidities in rheumatic diseases has not faded in the past decade; however, the concept of multimorbidity has not yet been integrated into either clinical practice or rheumatology researches. The terms comorbidity and multimorbidity are fr...

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Increasing attention in rheumatology is today paid to the detection of diseases at the earliest possible (preclinical) stages, which can contribute to a more favorable response to therapy. The preclinical period of a systemic autoimmune reaction is assumed to be related to dysregulation of immune in...

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In managing elderly patients with rheumatoid arthritis (RA), it is essential to maintain a balance between treatment efficacy and safety, particularly concerning the use of glucocorticoids (GCs). Despite decades of GC use in comprehensive RA therapy, questions regarding the optimal safe dose, treatm...

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The World Health Organization assigns cardiovascular diseases, cancers, chronic respiratory diseases, as well as diabetes mellitus and some other nosological entities, including mental and musculoskeletal disorders, to main non-communicable diseases. These are considered to be a major public health...

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According to modern concepts, myocarditis is an inflammatory disease of the myocardium, diagnosed on the basis of generally accepted histological, immunological, immunohistochemical criteria. Previously, most researchers believed that the most common cardiac extra-articular manifestation of rheumato...

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The lecture presents an update on the epidemiology, pathogenesis, clinical manifestations, diagnosis, differential diagnosis, and treatment stages of polymyalgia rheumatica, a chronic inflammatory disease of unknown etiology, which affects older people.----Authors of the article «Rheumatic polimyalg...

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At present, the role of the renin-angiotensin system (RAS) in regulating the cardiovascular system and maintaining water and electrolyte homeostasis has been well studied. However, over the past decades, new components of the RAS have been identified, suggesting a wider range of its potential effect...

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Systemic sclerosis (SS), is an autoimmune connective tissue disease, the main clinical signs of which are due to disseminated microcirculatory disorders and fibrosis of the skin and viscera. Morphological examinations showed that 80% of patients with SS had renal changes, including those unassociate...

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Increasing attention in rheumatology is currently paid to the detection of diseases in the earliest (preclinical) stages, which can contribute to a more favorable response to therapy. To this end, various clinical, laboratory (and primarily immunological) and instrumental parameters are studied as a...

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In 2008, the term cardiorenal syndrome (CRS) was proposed by the Acute Dialysis Quality Initiative (ADQI) Group to denote pathological reciprocal conditions involving the heart and kidneys, which develop due to acute or chronic dysfunction of one of the organs, followed by acute or chronic dysfuncti...

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Anemia is still one of the most common comorbidities that affects the prognosis of the underlying disease and the quality of life of patients.Objective: to evaluate the value of serum hepcidin level determination for the differential diagnosis of anemia of chronic disease/inflammation (ACD) in patie...

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Objective: to assess the presence and nature of multimorbidity in patients with rheumatoid arthritis (RA) and the impact of multimorbidity on disease activity.Patients and methods. The investigation enrolled 117 patients (mean age, 54.8+14.8years) with RA according to the 2010 ACR/EULAR criteria, wh...

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Objective: to compare the course of the disease and therapy in rheumatoid arthritis (RA) patients who meet and do not meet the criteria for difficult- to-treat RA (D2T).Patients and methods. The study included RA patients who met the 2010 ACR/EULAR criteria and who were hospitalized in the V.A. Naso...

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The widespread introduction into clinical practice of modern approaches to the treatment of rheumatoid arthritis (RA), the rational use of traditional and targeted antirheumatic drugs can effectively suppress inflammatory activity, restrain the progression of the disease and improve the quality of l...

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Several studies have shown that systemic rheumatoid inflammation may cause induction and accelerated progression of atherosclerotic vascular lesions, which in turn may lead to more frequent development of cardiovascular diseases (CVD) in patients with rheumatoid arthritis (RA) compared to the genera...

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