Search Results - A. S. Avdeeva

Calprotectin (CP) belongs to the S100 leukocyte protein family, consists of two calcium-binding protein molecules, S100A8 and S100A9 (MRP8/14, calgranulin A/B). MRP8/14 is the main intracellular protein of neutrophil granulocytes and monocytes, which exerts a proinflammatory effect on phagocytes, en...

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Immune-mediated rheumatic diseases (IMRDs) are a broad group of pathological conditions based on impaired immunological tolerance to one’s own tissues leading to inflammation and irreversible organ damage. Laboratory diagnosis of IMRDs includes a wide range of biomarkers (autoantibodies, acute phase...

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Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease characterized by chronic inflammation of joint synovial membrane and progressive destruction of bone and cartilage. Massive synovial infiltration with immune and inflammatory cells, such as macrophages, monocytes, granulocytes,...

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Rheumatoid arthritis (RA) is the most common and severe chronic joint inflammatory disease leading to early disability and shorter lifespan in patients. A number of studies have demonstrated that short-term and long-term prognosis of the disease is much more favorable in achieving remission in the e...

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In patients with immune-mеdiated (autoimmune) rheumatic diseases (IMIRD), there are a number of factors (advanced age, uncontrolled inflammation, initially irreversible damage to internal organs, comorbid pathology, genetic and other factors) that can potentially lead to an increase in “sensitivity”...

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Immunoinflammatory rheumatic diseases (IIRDs) are a large group of pathological conditions with impaired immunological tolerance to autogenous tissues, leading to inflammation and irreversible organ damage. The review discusses current ideas on the role of type I interferons in the immunopathogenesi...

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Rheumatoid arthritis (RA) is an autoimmune rheumatic disease characterized by chronic erosive arthritis (synovitis) and a systemic inflammatory lesion of the internal organs, which results in early disability and worse quality of life in patients. The accumulated data on the efficacy, safety, and co...

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Immune-mediated rheumatic diseases (IMRDs), based on the leading mechanisms of pathogenesis, are conditionally classified into autoimmune, autoinflammatory, and «mixed pattern». In the spectrum of cytokines involved in the development of the immunopathological process in IMRDs, the “pro-inflammatory...

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Digital technologies have become firmly embedded in all spheres of our life. Presently, it is almost impossible to imagine a single day without the use of gadgets and electronic devices. An important place in the modern world is occupied by the problem of socio-psychological adaptation, which takes...

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In the professional environment, socio-psychological adaptation to work occurs among workers, ordinary specialists and managers. The adaptation process is the most difficult for employees appointed to a managerial position for the first time. This is because they need not only to adapt to a new job,...

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The problem of interdisciplinary educational integration reflects the realities of the modern world. Rapidly changing technologies set new requirements for the training of specialists capable of innovation. The study of the vertical and horizontal interdisciplinary integration resources for the disc...

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The article analyzes the phenomenon of clip culture. Alvin Toffler’s information society dynamics concept has become the methodological basis of the research. The purpose of the study is to highlight the universal characteristics of clip culture considering the current state of the info- and technos...

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The article presents the results of a study carried out at Bauman Moscow State Technical University (National Research University) in order to identify students’ expectations regarding the directions of professional education transformation. Based on the results of the analysis of student’s essays,...

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The problem of adaptation to professional activity among representatives of different generations is acute. Currently, managers understand the need and importance of the adaptation process for new employees. But they do not always take into account the fact that employees belonging to different gene...

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The article considers the actual problem of organizing the communication space of distance learning for first-year students of the university. The development of information technologies, the need to introduce innovative approaches, the emergence of global extreme social situations, such as the COVI...

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Digital technologies development stimulates game elements inclusion into culture and different spheres of society. The identification of regularities and specifics of this process became the purpose of the study. The research methodology was based on the J. Huizing’s “man playing” concept and K. Ver...

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Systemic lupus erythematosus (SLE) is a systemic autoimmune rheumatic disease of unknown etiology, characterized by overproduction of organ-specific autoantibodies to various components of the cell nucleus and the development of immune-inflammatory damage to internal organs. According to modern conc...

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Depending on the epitope specificity of antineutrophil cytoplasmic antibodies (ANCA) and the presence or absence of a granulomatous inflammation. Patients with ANCA-associated vasculitis (AAV) show variability in clinical manifestations and prognosis depending on the epitope specificity of ANCA and...

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