Search Results - A. P. Pereverzev

Atrial fibrillation (AF) is one of the most prevalent rhythm disorders and might be associated with the high risk of thromboembolic complications, including stroke. For risk estimation, of the thrombotic complications, a variety of scores has been implemented, including CHA2DS2-VASc Score. According...

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Drug-induced fatty liver disease (DIFLD) covers a group of adverse drug reactions whose prevalence accounts for about 10% of all adverse reactions. The aim of this review was to analyse and summarise data on medicines that can potentially lead to the development of DIFLD, as well as on the pathophys...

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15-25% of cases of the medicatiom errors caused by the similarity in spelling or pronunciation of their names. The labelling may be a means of protection against such errors. The authors proposed a way of marking that is applied to each unit product information protective barcode labels containing i...

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Prevention of adverse events caused by medication errors is an important challenge of modern healthcare as it offers the possibility to reduce mortality, improve patient safety and reduce costs arosed from correction of complications. Two modern methods (Global Trigger Tool and Failure Mode and Effe...

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The article presents the results of a comparative analysis of Goodpharmacovigilance practices (GVP), developed by experts of the regulatory bodiesof the European Union (EU) and the United States. It is shown that the EU GVP cover almost all possible aspects of pharmacovigilance. It is noted that the...

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Comparative evaluation of information about adverse reactions to medicinal products was carried out on the basis of the research data registered in specialized databases WHO, Russia, Switzerland, USA and the Republic of Kazakhstan. Comparative evaluation of the results of safety monitoring medicines...

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New oral  anticoagulants are  effective for  the  prevention of thromboembolic complications in patients with atrial fibrillation, or after orthopedic surgery. The use  of these drugs may be associated with the  risk of bleeding from the  gastrointestinal tract — a dangerous complication, which can...

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Malnutrition is a patient’s condition with high relevance and importance for elderly patients (most often seen in very old patients >80 years old), since it is associated with a high risk of progressive worsening of their state, prolongation of hospitalization and death. Exposure to some drug...

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In this article authors analyze the influence of a label on drugpackage on the risk of medication errors and propose methods of their prevention.Analysis of the corresponding data published by regulators EMA and FDA hasprovided an opportunity to find examples of phonetic and graphic similaritieswith...

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This article provides the analysis of the updated versions of the existing legislative framework, regulating legal relations in the state registration of intellectual property. It considers expert views on the mentioned issue and provides with certain recommendations that are reasonable to be taken...

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Acetaminophen is one of the most commonly used analgesics /anti pyretics. However, taking into account the existing risk of hepatotoxicity,regulatory bodies of a number of the countries made additional adjustments tothe recommendations on the use of this drug. In the article the possible reasonsfor...

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For the treatment of dementia and Alzheimer’s disease, acetylcholinesterase inhibitors (donepezil, rivastigmine, galantamine) and/or the non-competitive inhibitor of N-methyl-D-aspartate receptors (NMDA receptors) memantine are currently used. The administration of these drugs can help temporarily i...

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Abstract. Elderly patients are at higher risk of developing infectious diseases that might have more severe progression than those of younger age groups, accompanied by an increased risk of death. These medical conditions in elderly may also present difficulties for diagnosis due to a «blurred» clin...

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The effectiveness of antiarrhythmic drugs in the elderly is similar to that in younger patients. However data for «the very elderly» are lacking. Elderly patients are more vulnerable to adverse drug reactions (ADRs) because of age-related changes of pharmacokinetics, co-morbidity and drug interactio...

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Use of class I antiarrhythmic drugs in the elderly is limited by their adverse drug reactions (ADRs), proarrhythmic effect (I A и I C) and high risk of drug interactions. Disopyramide use should be avoided due to its strong anticholinergic properties associated with the risk of cognitive and physica...

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In this article authors describe some existing methods of benefit / risk assessment.

The article presents the results of analysis of the use of drugs in the first trimester of pregnancy from the point of view of safety to the fetus

The article presents the mechanisms of development and methods of correction of myotoxicity associated with use of local anesthetics

The review addresses the issue of the gastrointestinal bleeding (GIB) development in patients receiving oral anticoagulants, and the proton pump inhibitors (PPIs) efficiency in reducing of such complications. Epidemiological data on the prevalence of GIB in the presence of nonwarfarin oral anticoagu...

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Abstract. The demographic aging of the population of the earth observed in recent years is associated, inter alia, with the advent of new effective and safe medicines. However, the availability of highly effective drugs on the market also has a reverse side — the appearance of adverse drug reactions...

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