Search Results - A. N. Samko

The introduction of drug-eluting stents has been a major achievement of interventional cardiology. These stents  demonstrate good clinical effectiveness and safety profile. However, prevention of restenosis and late stent thrombosis remains an important problem. The potential of antithrombotic treat...

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Objective: to study whether myocardial single-photon emission computed tomography (SPECT)/CT with radiation absorption correction (RAC) versus fractional flow reserve (FFR) may be used to assess the hemodynamic relevance of borderline coronary stenosis in patients with coronary heart disease (CHD).M...

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Introducing drug-eluting stents (DES) is an important achievement in interventional cardiology. These stents have demonstrated good clinical results, effectiveness and safety. Despite the decrease in restenosis incidence, the incidence of adverse coronary events remained the same as for standard met...

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Currently, cardiovascular diseases play a leading role in the structure of morbidity. It is expected that by 2020 in developing countries cardiovascular diseases will take the leading position in the structure of mortality. Among the diseases of the cardiovascular system the leading position is occu...

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No-reflow phenomenon is a complication of percutaneous coronary intervention and is the absence of distal coronary bed filling. The main cause of this phenomenon is distal embolism of the coronary artery by atheromatous and thrombotic masses. The paper gives different classifications for evaluation...

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The paper describes a patient admitted to the Emergency Cardiology Department, A.L. Myasnikov Institute of Clinical Cardiology, for diagnosed ST-segment elevation acute coronary syndrome. At the prehospital stage, the patient received ineffective thrombolytic therapy; percutaneous coronary intervent...

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Multiple coronary artery atherosclerotic lesions are a major cause of ischemic cardiomyopathy. Myocardial revascularization in patients with ischemic cardiomyopathy in the presence of the viable myocardium and/or ischemic areas leads to improved central hemodynamic parameters and as a consequence to...

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The review focuses on the gathered data related to preconditioning phenomenon and, particularly, pharmacological preconditioning of myocardium. The information presented, on the activator of ATP-dependent potassium channels nicorandil. Mechanism of action is discussed, as efficacy and safety data. T...

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The presented literature analysis is focused on the heart microvasculature and finding new ways to perform the method of deep coronary penetration technique. Also, new data reflecting the technique’s efficacy and safety are published on regular basis.

Even after performed mammary artery bypass surgery, some patients continued to have clinical manifestations of angina pectoris. This may be associated with the development of coronary stealing syndrome due to the fact that the native intrathoracic artery has large lateral branches. Current methods f...

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Aim. To study the possibility of reducing the risk of intraoperative cardiac damage and 4a type myocardial infarction (MI) by administering the oral nicorandil in patients with a stable form of coronary artery disease (CAD) before planned percutaneous coronary intervention (PCI).Material and methods...

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Aim.  to study the significance of residual platelet reactivity (RPR) to adenosine diphosphate (ADP) and carriage of the gene cythochrome P450 CyP2C19 polymorphisms in relationship to the bleeding risk in stable CHD patients, undergoing planned PCI and receiving double antiplatelet therapy with aspi...

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Objective: to determine the efficiency and safety of manual thrombus aspiration (TA) in patients with acute ST-segment elevation myocardial infarction.Material and methods. The investigation enrolled 200 patients with ST-segment elevation myocardial infarction. According to prehospital therapy, all...

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Aim. To study nicorandil prescription effects before elective percutaneous coronary intervention (PCI) to prevent myocardial injury and 4a type acute myocardial infarction (MI, primary endpoint) and cardiovascular events (CVE) in the first year after PCI (secondary endpoint) in patients with stable...

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Atherosclerotic peripheral artery disease (PAD) is well-known thrombotic risk factor in different cohorts of patients. This current review analyzes epidemiological data of trials and registries about influence both clinical and asymptomatic peripheral atherosclerotic disease on adverse ischemic even...

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Aim. To study content of resident progenitor cardiomyocytes in endomyocardial biopsy samples of patients with dilated cardiomyopathy (DCM) and heart failure (HF) at different disease stages and relate it to patient clinical characteristics.Material and methods. Resident progenitor cardiomyocytes wer...

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Background. Vitamins В6 В12 and folic acid (FA) therapy to reduce cardiovascular risk appears to be unreasonable. Negative results of recent large-scale trials might be due to high daily doses of the vitamins and widespread FA fortification programmes. Russian population is known to have high preval...

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Aim. To study  prognostical  significance  of vasomotor  disorder  of coronary  and brachial  arteries,   and  traditional  risk factors  in development   of  cardiovascular complications in patients with microvascular angina (MVA) and cardial syndrome X; a retrospective 12-year observation.Material...

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Aim. To study the links between four polymorphisms of three antioxidant enzymes (catalase, paraoxonase, endothelial NO synthase) and restenosis risk after coronary artery stenting (CAS).Material and methods. The study included male patients with coronary heart disease (CHD), stable angina and angiog...

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Aim. To study perspectives of reducing incidence and severity of coronary artery (CA) restenosis by adding a low dose of antioxidant agent Probucol (250 mg/d) to the treatment before and after transluminal balloon coronary angioplasty (TBCA). Material and methods. The study included 81 patients (mea...

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