Search Results - A. N. Meshkov

Platelets play an important role in the pathogenesis of atherosclerosis. They are involved in atherosclerosis progression and thrombotic complications. That is why antiplatelet therapy is a necessary element of these complications prevention in patients with coronary heart disease. One of the most c...

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Assessment of lipid-lowering effect of rosuvastatin is presented, as well as the main results of the study of rosuvastatin therapy efficacy , in comparison with other statins, received in controlled clinical trials of the GALAXY program: COMETS, LUNAR, MERCURY-I, SOLAR, STELLAR.

Large epidemiological trails shown that hypercholesterolemia is one of the main risk factor of ischemic heart disease (IHD). Correction of the hypercholesterolemia with GmGKoA reductase inhibitors (statins) essentially reduces IHD morbidity and mortality. The lower serum level of low density lipopro...

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The review is devoted to modern views on hypertriglyceridemia (HTG) etiology and pathogenesis, and its casual role in some disease development. Data on normal TG metabolism, main causes of HTG, its clinical role and diagnostics are discussed. Even though HTG plays an important role in atherosclerosi...

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Currently, cardiovascular diseases (CVD) remain the main problem in the world and in Russia in particular. The study of the causes and progression of atherosclerosis is a critical moment in the fight against CVD. Adipose tissue and processes that occur in it attracts attention in recent years. The i...

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The sequencing of first human genome followed by rapid development of technologies, that led to significant lowering of costs for genetic analyze and its fast performing, made possible a broad invention of genetic diagnostics methods into clinical practice. Contemporary methods of molecular genetics...

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The further development of preventive medicine in the 21st century may be impossible without the assessment of individual patients’ genetic data. At present, genetic methods are the gold standard in the diagnostics of monogenic diseases. Recently, genetic factors linked to complex (multifactorial) d...

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Smoking is one of the main factors of a wide range of diseases as ischemic heart disease, stroke, chronic obstructive pulmonary disease. To know mechanisms of smoking influence on the course of these diseases might lead to discovery of novel methods of diagnostics and prevention. Recent studies show...

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Circulating microribonucleic acids (microRNAs) are promising biomarkers of various diseases, but their clinical laboratory use requires highly sensitive, reproducible, reliable and sustainable methods for their accurate plasma and serum quantification. The preanalytical phase of studies conducted us...

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Over the past decade, circulating small non-coding ribonucleic acid molecules (microRNAs) have demonstrated their potential as minimally invasive diagnostic and prognostic biomarkers of various diseases. Standardization of preanalytical and analytical factors, including collection, processing and st...

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Numerous studies demonstrate an independent relationship between an increase in the blood content of triglyceride-rich particles and the risk of atherosclerotic cardiovascular diseases and acute pancreatitis. This review article presents in detail aspects of the pathogenesis of various types of prim...

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Hypertriglyceridemias are a heterogeneous group of pathologies differing in the mechanisms of triglyceride-rich lipoprotein increase, the composition of lipoproteins and related risks. This review article presents information on the profile and pathogenesis of various primary and secondary hypertrig...

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Familial hypercholesterolemia (FHCH) is characterised by early atherosclerosis development and its fast progression. The prevalence of FHCH inRussiahas been increasing, therefore, it is important to evaluate the potential of various methods for atherosclerosis diagnostics. Arterial ultrasound is an...

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Aim. To estimate the effectiveness of lipid-lowering therapy (LLT) at outpatient and hospital treatment stages in patients at high and very high cardiovascular risk during 2011-2015.Material and methods. In a cross-sectional epidemiological study we analyzed LLT in hospital patients for the period A...

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Current prophylactic actions prevent or significantly delay the majority of cardiovascular diseases (CVD). Various factors are interconnected and affect a person throughout his life, determining the risk of CVD. This indicates the need for preventive measures at all stages of life and even before bi...

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Aim. To identify character and prevalence of apolipoprotein (apo) B-100 gene mutation in patients with clinical diagnosis of heterozygote familial hypercholesterolemia (FH); to describe its phenotypical features in mutation carriers. Material and methods. In 111 patients with clinical diagnosis of h...

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High-throughput sequencing of small ribonucleic acid (RNA) molecules is widely used to search for markers of various diseases, as well as to study the regulation of gene expression. The data processing protocol consists of many stages, including the stages of analyzing the initial data quality and s...

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Familial dysbetalipoproteinemia (FD) is a genetic, highly atherogenic disorder. The penetrance of FD depends on the patient’s lifestyle and concomitant diseases. Despite the fact that FD was described almost half a century ago, it is still insufficiently studied and is extremely rarely diagnosed. In...

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Aim. To study clinical course and severe complication development in patients with severe hypertriglyceridemia (HTG), >10 mmol/l. Material and methods. The study included 75 patients aged 21-68 years (mean age 49±11,05 years), examined at the Cardiology Complex in 1982-2006, with verified fas...

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Aim. To assess coronary heart disease (CHD) and its risk factors (RF) prevalence, as well as their interaction in patients with heterozygotic form of familial hypercholesterolemia (FHCH). Material and methods. The analysis included 200 patients aged 24 years and above, with clinical diagnosis of FHC...

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