Résultats de la recherche - A. E. Skvortsov
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REHABILITATION OF ORGAN FROM DECEASED DONORS. NEW PRESERVATION TREND OR NEW PARADIGM IN TRANSPLANTOLOGY?
Publié 2009-05-01Accéder au texte intégralThe articleis is dedicated to the main problem of transplantology which is shortage of acceptable donors’ organs. The tendency of expanding the donor’s pool should include policy of prevention and reduction the ischemia- reperfusion trauma of donor’s organs. The crucial role of machine perfusion in...
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BIOBANKS ARE AN ESSENTIAL TOOL FOR TRANSPLANTATION. HISTORY, CURRENT STATE, PERSPECTIVES
Publié 2017-01-01Accéder au texte intégralOrgan shortage remains to be a crucial issue in transplantation. However, it’s not the only challenge that modern transplantation is facing. There are critical issues to be solved, such as, choosing optimal patient-specific immunosuppressive regimen, preventing or coping effectively with graft rejec...
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The effect of phosphodiesterase-5 inhibitors on the alveolar blood fl ow in the pulmonary graft
Publié 2016-01-01Accéder au texte intégralLung transplantation – an effective way to radical surgical treatment of chronic lung disease in the terminal stage. The use of drugs with extending effect on vascular smooth musculature of the pulmonary circulatory system, prior to conservation and assessment of the functional state of the microvas...
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Sensitivity of the Baroreceptors and the State of the Autonomic Nervous System in Patients with Chronic Impairment of Consciousness Due to Severe Brain Damage
Publié 2019-11-01Accéder au texte intégralPurpose of the study: to examine sensibility of baroreceptors and the autonomic nervous in the passive orthostatic test in patients with chronic impairment of consciousness due to severe brain damage and determine their role in the rehabilitation process.Materials and methods. The study included 30...
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Diagnostic possibilities of using micro-RNA for kidney transplantation
Publié 2018-09-01Accéder au texte intégralAllogeneic kidney transplantation is the optimal approach for the treatment of patients with terminal stage of chronic kidney disease. Moreover, post-transplant monitoring and optimization of immunosuppressive therapy with early non-invasive molecular-biological markers can significantly improve t...
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PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION
Publié 2013-03-01Accéder au texte intégralGlobal organ shortage is the crucial point of transplantation nowadays. Usage of expanded criteria donors represents reliable source of donor organs, making transplantation more accessible for patients with end stage organs failure. Ischemia-reperfusion injury followed by the activation of programme...
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Perfusion device for liver preservation ex vivo before transplantation: first experimental study
Publié 2017-04-01Accéder au texte intégralIntroduction. Successful liver transplantation including from donors with a sudden irreversible cardiac arrest requires the use of modern hardware and technical support to maintain, select and sustain organ viability for the period from harvesting to transplantation to the recipient.Materials and me...
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LAPAROSCOPIC NEPHRECTOMY IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
Publié 2016-11-01Accéder au texte intégralAim. To assess the possibilities of the use of laparoscopic transabdominal nephrectomy (LNE) for surgical treatment and preparation of the patients with autosomal dominant polycystic kidney disease (ADPKD) for kidney transplantation. Materials and тethods. In the course of the study 28 patients who...
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NORMOTHERMIC EXTRACORPORAL PERFUSION IN SITU AS A WAY OF RECOVERY KIDNEY TRANSPLANTS FROM DONORS WITH SUDDEN IRREVERSIBLE CARDIAC ARREST
Publié 2010-06-01Accéder au texte intégralThe potential of donors after cardiac death is actual issue. The crucial point in uncontrolled donors after cardiac death is the warm ischemical time. Definition of the limit of warm ischemic time is was the one task of our work and other one is development of preservation protocol saving quality of...
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FIRST EXPERIENCE IN SYSTEMIC ADMINISTRATION OF EVEROLIMUS IN RENAL TRANSPLANTATION FROM EXPANDED CRITERIA DONORS IN RUSSIAN FEDERATION
Publié 2017-01-01Accéder au texte intégralIntroduction. Kidney transplant (KTx) with reduced functional reserve is more sensitive to the toxic effects of calcineurin inhibitors (CNI). Immunosuppressive therapy (IST) approach with m-TOR inhibitors in case of KTx from expanded criteria donors (ECD) leads to decreasing levels of cyclosporine (...
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NORMOTHERMIC EXTRACORPOREAL PERFUSION IN SITU IN DECEASED ORGAN DONORS WITH IRREVERSIBLE CARDIAC ARREST AND ONE HOUR OF ASYSTOLE. 5-YEAR OUTCOMES OF KIDNEY TRANSPLANTATION
Publié 2016-11-01Accéder au texte intégralAim. The global shortage of deceased organ donors caused increasing interest to the transplant program based on the use of organs from the donors with sudden irreversible cardiac arrest, or asystolic donors (DCD). Ischemia-reperfusion injury as a result of cardiac arrest remains a key problem that l...
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First Russian experience of liver and kidneys transplantation obtained from the donor with out-of-hospital irreversible cardiac arrest
Publié 2019-05-01Accéder au texte intégralOrgans’ shortage remains the main limiting problem for accessibility of organ transplantation. There is the growing interest among transplant society for use organs obtained from «uncontrolled» donors after cardiac death (uDCDs), or, asystolic donors. But the warm ischemic time is critical factor fo...
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Aortic valve replacement for patient with infective endocarditis early after liver transplantation with a complete withdrawal of immunosuppressive therapy
Publié 2017-12-01Accéder au texte intégralThe number of patients with severe liver failure awaiting transplantation is increasing steadily. The shortage of donor organs, in turn, leads to long waiting time for liver transplants and increases the likelihood of decompensation and progression of the disease, significantly increasing the propor...
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First Russian experience in liver and kidney transplantation from donors with out-of-hospital cardiac arrest: 3 years’ results
Publié 2021-09-01Accéder au texte intégralIntroduction. In megacities, the use of organs obtained from those who died as a result of sudden out-of-hospital cardiac arrest (OHCA) for transplantation is one of the promising ways of addressing the problem of organ donor shortage. In St. Petersburg, the model of transition from life support via...
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